Three speakers from the 2010 In-Process Particle Forum will present at IFPAC [International Forum Process Analytical Technology] on January 21, 2011 in Baltimore, MD. Steve Mehrman of Johnson & Johnson and James Butz of Merck & Co. are scheduled to present during the Particle Characterization/Analysis-Ultrasound Spectroscopy Friday AM V session at IFPAC. Kevin Macias of Bristol-Myers Squibb will present during the Control Strategies for Drug Product Development and Manufacturing Friday AM VII session. Continue reading →
Often, I hear questions surrounding what are liquid dosage formulations. I thought I might take the opportunity to provide a short introduction to liquid dosage formulations. Liquid dosage formulations may be in the form of suspensions or syrups, metered dosed inhalers (MDIs), or creams or lotions. All of these systems would typically have particles present or droplets present in their formulations. There could also be parentals, such as injections or intravenous infusions, which may be particle free. Continue reading →
At the 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting in Salt Lake City, there were a number of well-attended sessions dealing with the related topics of Quality by Design (QbD) and Process Analytical Technologies (PAT). Continue reading →
When validating a method according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, it is necessary to perform a linearity experiment. This requires the preparation of multiple calibration levels, analysis of the samples by liquid chromatography, and calculation/reporting of the results. Each of these steps can be very time consuming, and in many cases error prone. This is especially true if the analytical method being tested requires the measurement of multiple components. Continue reading →
As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR. In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines. For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.
In 1969, the USA Congressional Joint Committee on Atomic Energy held a hearing at the head of the Fermi National Accelerator Laboratory and was being questioned on why build a new $250 million particle collider. What did a particle collider have to do with the security of the country? Physicist Robert Wilson replied “It has nothing to do directly with defending our country except to make it worth defending.” 1
Last month, I attended the 11th International Petrophase Conference in New Jersey, USA. Topics discussed at the 11th International Petrophase Conference included petroleum phase behavior, the formation and mitigation of organic solid phases, emulsions and colloids, desalting, and the structure and composition of heavy oils, asphaltenes, and trace contaminants. After speaking with several other delegates, I was reminded that there are few process analytical instruments that could measure droplets or particles within crude oil or at elevated pressure field installations. Continue reading →