Tag Archives: Webinar

IFPAC 2011上谈PAT与颗粒大小分析

2010工艺过程中的颗粒论坛会上的三位报告者将在2011年1月21日于(美国)马里兰州的巴尔的摩举行的IFPAC (工艺过程分析技术国际论坛)上作报告。Johnson & Johnson的Steve Mehrman和Merck & Co. 的James Butz被排在周五上午的“颗粒特征分析超声光谱”IFPAC 的第五分会作报告。Bristol-Myers Squibb的Kevin Macias将在周五上午的“药品开发与生产的控制战略”第七分会中作报告。 Continue reading

PAT & Particle Size Analysis at IFPAC 2011

Three speakers from the 2010 In-Process Particle Forum will present at IFPAC [International Forum Process Analytical Technology] on January 21, 2011 in Baltimore, MD.  Steve Mehrman  of Johnson & Johnson and James Butz of Merck & Co. are scheduled to present during the Particle Characterization/Analysis-Ultrasound Spectroscopy Friday AM V session at IFPAC.  Kevin Macias of Bristol-Myers Squibb will present during the Control Strategies for Drug Product Development and Manufacturing Friday AM VII session. Continue reading

What are Liquid Dosage Formulations?

Often, I hear questions surrounding what are liquid dosage formulations.  I thought I might take the opportunity to provide a short introduction to liquid dosage formulations.  Liquid dosage formulations may be in the form of suspensions or syrups, metered dosed inhalers (MDIs), or creams or lotions. All of these systems would typically have particles present or droplets present in their formulations. There could also be parentals, such as injections or intravenous infusions, which may be particle free. Continue reading

PAT at AIChE 2010 – Real-time Monitoring of Granulation and Roller Compaction

At the 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting in Salt Lake City, there were a number of well-attended sessions dealing with the related topics of Quality by Design (QbD) and Process Analytical Technologies (PAT). Continue reading

Workflow for Linearity Testing using Automated Sample Preparation and UHPLC

When validating a method according to the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, it is necessary to perform a linearity experiment. This requires the preparation of multiple calibration levels, analysis of the samples by liquid chromatography, and calculation/reporting of the results. Each of these steps can be very time consuming, and in many cases error prone. This is especially true if the analytical method being tested requires the measurement of multiple components. Continue reading

Recent Chemistry Research from ACS Journals Citing Use of In Situ FTIR

As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR.  In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines.  For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.

Continue reading

Advanced Energetic Materials: Improving Reaction Safety and Particle Size Distributions

In 1969, the USA Congressional Joint Committee on Atomic Energy held a hearing at the head of the Fermi National Accelerator Laboratory and was being questioned on why build a new $250 million particle collider.  What did a particle collider have to do with the security of the country?  Physicist Robert Wilson replied “It has nothing to do directly with defending our country except to make it worth defending.” 1

Continue reading

11th International Petrophase Conference in New Jersey

11th International Petrophase Conference
Last month, I attended the 11th International Petrophase Conference in New Jersey, USA.  Topics discussed at the 11th International Petrophase Conference included petroleum phase behavior, the formation and mitigation of organic solid phases, emulsions and colloids, desalting, and the structure and composition of heavy oils, asphaltenes, and trace contaminants.  After speaking with several other delegates, I was reminded that there are few process analytical instruments that could measure droplets or particles within crude oil or at elevated pressure field installations. Continue reading

Importance of Mixing in Scale-up: Comparing Lab and Large Scale

Mixing Scale-up Webinar METTLER TOLEDO

Compare Lab Scale Mixing with Full Scale Process Vessel Performance

Various physical and chemical processes interact during a manufacturing or synthesis process in a stirred tank reactor, including:

  • Kinetics
  • Heat Transfer
  • Thermodynamics; Equilibrium
  • Mass transfer between phases
  • Mixing to disperse multiple phases
  • Physical property changes
  • Continue reading