Tag Archives: University College Dublin

Polymorph Form Control: Why Care About Seeding and Cooling Rates?

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Mark Barrett and others at the University College Dublin (UCD) recently published a paper Continue reading

How To Optimize Crystal Size Distribution, Improve Filtration Rates, and Batch Consistency


Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Continue reading

AIChE 2010 年会 — 结晶过程

从阅读即将召开的2010 美国化工学会年会的技术内容中, 我注意到以下数篇涉及结晶工艺过程工作的人员会感兴趣的报告:http://cn.mt.com/cn/zh/home/events/fairs/AiChE-2010.html?=US_AC_eAdv_zhBlog

  • 包括工艺放大的用于Drown-out 结晶过程的工艺模拟手段, Eleftherios Kougoulos – Pfizer
  • 用PAT (工艺过程分析技术)定性分析快速结晶工艺过程, Barbara Wood – University College Dublin
  • 结晶工艺自动化平台: 集成硬件、软件、和PAT来促进结晶工艺过程的开发, Amanda Rogers – Bristol-Myers Squibb
  • 应用PAT来定义设计空间从而实现结晶工艺过程的控制战略, George Zhou – Merck & Co.
  • 在一个工业化半釜式糖结晶釜中实时监测晶体成核和增长速率, Terry Redman – METTLER TOLEDO
  • 结合工艺过程分析技术的结晶过程放大–确保从R&D 实验室到生产厂的成功, Terry Redman – METTLER TOLEDO
  • PAT在设计和优化塞流结晶系统中的应用, University College Dublin
  • 在2,6-Diamino-3,5-Dinitropyrazine-1-Oxide (LLM-105) 重结晶中应用原位技术, Andrew G. Pearsall – Naval Surface Warfare Center
  • 建立一个从起始晶种分布预测过饱和度和晶体大小的结晶过程模型的成功与挑战, James Vernille – Bristol-Myers Squibb


Crystallization at the AIChE 2010 Annual Meeting

While reviewing the technical program for the upcoming 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed several papers of interest to those of us who work in crystallization: Continue reading

Process Analytical Technology (PAT) for Crystallization Optimization & Scale-up: Research From The Crystallization Cluster at University College Dublin

Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant – Parts I & II.

This two part crystallization webinar series given by Mark Barrett on January 27 and February 3 is now available on-demand.   View the Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process on-demand webinar.

The webinar series, based on an award winning paper presented at the 16th International Process Development Conference, focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.