Tag Archives: Spectroscopy

Use a Continuous Flow Reactor to Monitor Product Streams & Dispersion Effects

A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode.   Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated.  Continue reading

Polymorph Form Control: Why Care About Seeding and Cooling Rates?

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Mark Barrett and others at the University College Dublin (UCD) recently published a paper Continue reading

Is Lithium Salt More Like Organolithium Or Azaenolate?

2-Lithio-3,3-dimethyl-2-oxazolinyloxirane: Carbanion or Azaenolate?

Vito Capriati*, Saverio Florio*, Renzo Luisi, Filippo Maria Perna and Agnese Spina
Dipartimento Farmaco-Chimico, Università di Bari, Consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy; J. Org. Chem., 2008, 73 (24), pp 9552–9564.

Structure, Configurational Stability and Stereodynamics in Solution
During this work, Vito Capriati, Saverio Florio and colleagues at the University of Bari in Italy used in situ Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectroscopy together to give a better insight into the stability of lithium salt and to ultimately answer the question:

“Is the lithium salt more like an organolithium or is it more like an azaenolate?”
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Metal Catalyzed Transformations Using In Situ Spectroscopy

Metal Catalyzed Transformations have been a key topic in academic research for a number of years, both for their scientific interest, as well as the large number of reactions that have become important to industry. Continue reading

What is Continuous Flow Chemistry?

httpv://www.youtube.com/watch?v=A7Gb7sF4sjk

Continuous flow chemistry is widely used in the chemical and petrochemical markets, and has been for decades.  The continuous flow chemistry production methodology has been gaining interest in pharmaceutical R&D due to: Continue reading

Recent Chemistry Research from ACS Journals Citing Use of In Situ FTIR

As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR.  In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines.  For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.

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1st Annual RSC/SCI Continuous Flow Symposium

Jon Goode, Nigel Gaunt, and I attended the 1st Annual Royal Society of Chemistry (RSC)/Society of Chemical Industry (SCI) Continuous Flow Symposium held last week at GlaxoSmithKline in Stevenage, United Kingdom.  Considering that this was the first time this particular event was held, it was very well attended.  This was yet another reminder of what seems to be an ever increasing interest in continuous flow. Continue reading

How To Study Chemistry Under Actual Reaction Conditions

Traditional offline methods to analyze reaction chemistry, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC), share a common problem: when a sample is removed for analysis, it may be altered or compromised resulting in significant analytical errors. The solution for this is Continue reading