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Optimization and Scale-up of High Shear Wet Granulation Processes

GlaxoSmithKline-GSK-granulation-measurement-FBRM-C35

FBRM® C35 with mechanical wiper for in situ granulation measurement

One goal of high shear granulation is to yield repeatable endpoint granule size, shape, and density distributions. This is necessary for consistent downstream flow properties, tablet consistency, and content uniformity. Quality by Design (QbD) is a concept applied to gain true process understanding through tools such as Design of Experiment (DoE), risk management, and Process Analytical Technology (PAT).

This extended abstract summarizes collaborative research between GlaxoSmithKline (GSK) and METTLER TOLEDO in the application of process analytical technologies (PAT) to the monitoring, optimization and control of High Shear Wet Granulation.

Download the extended abstract for this upcoming conference presentation.

Authors:
Zane Arp, GSK
Eric Dycus, Ben Smith, METTLER TOLEDO
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