Tag Archives: Simon Rea

SERMACS 2012 – Southeastern Regional Meeting of the American Chemical Society

How to do more with less is a consistent theme in today’s chemical development laboratories. Researchers are challenged with how quickly and cost-effectively they can deliver high quality chemical products and the processes used to make them. This in turn has driven a trend in industry to develop and adopt new methods of working, and new techniques to analyze chemical reactions. Continue reading

化学动力学实验的教学方法

研究人员们(特别是有机化学师与分析化学师们)所面临的主要挑战包括需要快速地得知反应动力学,并获得足够的信息以便充分理解、鉴定和优化化学反应。这样的挑战致使研究人员们寻找新的方法来获得能使他们工作成功所需的信息。

化学反应动力学实验

在三月三十日的网络研讨会–反应动力学实验教学的创新方法–上,Seton Hall大学有机与有机金属化学系的 John R. Sowa Jr.教授介绍了如何进行基本动力学实验。Sowa 教授报告中讲得方法既可用于学术研究也可用于工业研发。

Sowa 教授的著名文章包括:

Joseph P. Simeone, John R. Sowa, Jr., “Palladium on carbon as a precatalyst for the Suzuki-Miyuara cross-coupling of aryl chlorides,” Tetrahedron, 2007, 63, 12646-12654.

Editor, Catalysis of Organic Reactions (Chemical Industries Series, Vol. 104), CRC Press, Boca Raton, Florida, 2005.

Suzuki-Miyaura Coupling with Quasi-Heterogeneous Palladium”. Conlon, D. A., Pipik, B., Ferdinand, S., LeBlond, C. R., Sowa, J. R. Jr., Izzo, B, Ho, G.-J., Williams, J. M., Shi., Y.-J., Sun, Y.-K. Adv. Synth. Catal., 2003, 345, 931-935.

增强对结晶工艺过程的理解

科学家与工程师们经常要面对的一个挑战是如何做到增强对结晶工艺过程的理解。

EasyMax为使这些科学家与工程师们完成大量的所需工作提供了一个即功能强大又使用便捷的实验平台。看到EasyMax已被他们欢迎采纳,尤其是针对结晶工作,使人感到欣慰。Simon Rea开发了一个方法,使EasyMax更适于颗粒特征分析:

结晶终于,您可以在您的EasyMax 里同时使用FBRM和PVM了! 这一新的PTFE封盖使您有可能观察到:

  • 多晶型/晶习的改变
  • 晶种添加行为
  • 相分离
  • 工艺过程中通常的颗粒/液滴的变化

并且,这可在体积小到30毫升条件下实现!当您要放大至1升时,您还可以把同一个PVM拿到那个规模的实验中使用

要通过例子看您可以在EasyMax 里同时使用FBRM和PVM来做什么,请浏览由固态制药团队(SSPC)的Mark Barrett所作的 从实验室到生产厂反溶剂添加结晶过程的优化与放大网络研讨会系列

Enhance Your Understanding of a Crystallization Process

A common challenge faced by both chemists and engineers is how to achieve an enhanced understanding of the crystallization process.

The EasyMax has provided a powerful, yet nimble platform for chemists and engineers to get a lot of work done.  It has been great to see how well the EasyMax has been embraced, especially for crystallization work.  Simon Rea developed a way to make it even better for particle characterization:

Crystallization Process FBRM PVM EasyMax

At last, you can use the FBRM and PVM simultaneously in your EasyMax!  This new PTFE lid makes it possible to see your: Continue reading

Methods For Teaching Chemical Kinetic Experiments

Some of the major challenges faced by researchers (and in particular – organic and analytical chemists) include the need to quickly determine reaction kinetics as well as gain sufficient information to fully understand, characterize and optimize chemical reactions.  This is leading researchers to find innovative ways to obtain the information they require to successfully complete their work.

Continue reading

自动化结晶过程开发

我最近作了一个网络研讨会报告: 自动化结晶过程开发: 亚稳态区宽度的确定和超饱和度的控制,该报告总结了一个用两天时间与一个大制药公司进行的合作,此合作缩短了结晶过程开发时间并提高了工艺放大效率。

结晶过程开发的自动化在这一报告中,我回顾了进行过饱和度控制实验的每一个步骤,根据所选不同过饱和程度结晶出不同的晶粒大小和分布。自动化这些实验显著地节约了时间,同时也增强了把小试条件转换到大规模生产的能力。我还具体地讨论了如何进行自动化的亚稳态区宽度研究。

如果你没能参加我的自动化结晶过程开发报告, 请求既有版现已在网上。

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Automating Crystallization Development

On Wednesday, I presented an online seminar: Automating Crystallization Development: Metastable Zone Width Determination and Supersaturation Control, which summarized a two day collaboration with a major pharmaceutical company where crystallization development time was reduced and scale-up efficiency was improved. Continue reading

Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading