How to do more with less is a consistent theme in today’s chemical development laboratories. Researchers are challenged with how quickly and cost-effectively they can deliver high quality chemical products and the processes used to make them. This in turn has driven a trend in industry to develop and adopt new methods of working, and new techniques to analyze chemical reactions. Continue reading
Dave Johnson and I attended the 7th eChemExpo Conference at the Meadowview Convention Center in Kingsport, TN on May 23. Continue reading
在三月三十日的网络研讨会–反应动力学实验教学的创新方法–上，Seton Hall大学有机与有机金属化学系的 John R. Sowa Jr.教授介绍了如何进行基本动力学实验。Sowa 教授报告中讲得方法既可用于学术研究也可用于工业研发。
Joseph P. Simeone, John R. Sowa, Jr., “Palladium on carbon as a precatalyst for the Suzuki-Miyuara cross-coupling of aryl chlorides,” Tetrahedron, 2007, 63, 12646-12654.
Editor, Catalysis of Organic Reactions (Chemical Industries Series, Vol. 104), CRC Press, Boca Raton, Florida, 2005.
Suzuki-Miyaura Coupling with Quasi-Heterogeneous Palladium”. Conlon, D. A., Pipik, B., Ferdinand, S., LeBlond, C. R., Sowa, J. R. Jr., Izzo, B, Ho, G.-J., Williams, J. M., Shi., Y.-J., Sun, Y.-K. Adv. Synth. Catal., 2003, 345, 931-935.
要通过例子看您可以在EasyMax 里同时使用FBRM和PVM来做什么，请浏览由固态制药团队（SSPC）的Mark Barrett所作的 从实验室到生产厂反溶剂添加结晶过程的优化与放大网络研讨会系列。
A common challenge faced by both chemists and engineers is how to achieve an enhanced understanding of the crystallization process.
The EasyMax has provided a powerful, yet nimble platform for chemists and engineers to get a lot of work done. It has been great to see how well the EasyMax has been embraced, especially for crystallization work. Simon Rea developed a way to make it even better for particle characterization:
At last, you can use the FBRM and PVM simultaneously in your EasyMax! This new PTFE lid makes it possible to see your: Continue reading
Some of the major challenges faced by researchers (and in particular – organic and analytical chemists) include the need to quickly determine reaction kinetics as well as gain sufficient information to fully understand, characterize and optimize chemical reactions. This is leading researchers to find innovative ways to obtain the information they require to successfully complete their work.
我最近作了一个网络研讨会报告： 自动化结晶过程开发: 亚稳态区宽度的确定和超饱和度的控制，该报告总结了一个用两天时间与一个大制药公司进行的合作，此合作缩短了结晶过程开发时间并提高了工艺放大效率。
On Wednesday, I presented an online seminar: Automating Crystallization Development: Metastable Zone Width Determination and Supersaturation Control, which summarized a two day collaboration with a major pharmaceutical company where crystallization development time was reduced and scale-up efficiency was improved. Continue reading
Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject: “Precaution during scale-up of a Grignard reaction?”. This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading