Tag Archives: safe scale-up

Process Development at AIChE 2010

While reviewing the agenda for next month’s American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed a number of papers and posters discussing process development in pharmaceuticals, chemicals, and academia: Continue reading

Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading