At the 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting in Salt Lake City, there were a number of well-attended sessions dealing with the related topics of Quality by Design (QbD) and Process Analytical Technologies (PAT). Continue reading
A couple of weeks ago, I posted an article about my colleagues’ attendance at POWTECH in Nuremberg. I was recently informed that while in Nuremberg, they accepted an award for this year’s most outstanding innovation in the field of Particle Characterization and Material Science at POWTECH. I thought I would share some of the details with you:
At the 2009 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in Los Angeles, Gerald Burke presented a case study on how Patheon Pharmaceuticals improved roller compaction processes. Specifically, the case study focused on the influence of roller compactor settings on Critical Quality Attributes (CQAs) and the early prediction and control of granule porosity. Continue reading
A successful process based on roller compaction followed by milling should produce a granule with consistent particle size distribution, density, and porosity control. Inconsistencies often occur during granulation scale-up due to changing raw materials or changing process dynamics.