Tag Archives: reaction monitoring

Challenges of Continuous Flow Chemistry

During the recent online seminar – Application of the ReactIR Flow Cell to Continous Processing Technology, Professor Steven Ley discussed the challenges of continuous flow chemistry.  According to Professor Ley, one of the main challenges of continuous flow chemistry is real-time inline reaction monitoring for gaining additional control over reactions, especially when dealing with multistep synthesis sequences.

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ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Developments in continuous flow chemistry: an article by Professor Steven Ley of Cambridge University was just published on the OPRD (ACS) website.


ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing.
Catherine F. Carter†, Heiko Lange†, Steven V. Ley*†, Ian R. Baxendale†, Brian Wittkamp‡, Jon G. Goode§ and Nigel L. Gaunt§

† Innovative Technology Centre, University of Cambridge.
, ‡ Mettler-Toledo AutoChem, U.S.A.
, § Mettler-Toledo AutoChem, UK.

Org. Process Res. Dev., Article ASAP
DOI: 10.1021/op900305v
Publication Date (Web): February 1, 2010
Copyright © 2010 American Chemical Society

How To Understand and Control Polymer Synthesis

How to Understand and Control Polymer Synthesis Webinar

How To Understand and Control Polymer Synthesis

Dr. Jennifer Andrews of METTLER TOLEDO will present a free online seminar Improving the Understanding and Control of Polymer Synthesis Using Real-Time In Situ FTIR on July 27.  During this presentation, Jennifer will discuss emerging polymer research and how to use real-time in situ Fourier Transform Infrared Spectroscopy (FTIR) to the understand polymerizations.

The importance of real-time in situ reaction monitoring for polymerizations is due in part to the fact that many polymerization reactions are run at high temperatures and/or pressures, some are extremely oxygen sensitive and many involve the use of hazardous reagents.

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How To Streamline Kinetics Studies Using Reaction Progress Kinetic Analysis (RPKA)

Check out this 2-minute video for a quick tour of how Reaction Progress Kinetic Analysis (RPKA) and iC Kinetics can streamline and accelerate kinetics studies.


For a more detailed look at RPKA, check out this Free On-Demand Webinar (presented by Prof. Donna Blackmond): Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions.

The Reaction Progress Kinetic Analysis (RPKA) Methodology, pioneered by Prof. Donna G. Blackmond of The Scripps Research Institute, requires far fewer reaction progress experiments than the classic kinetics approach. It accomplishes this by exploiting the extensive data available from accurate in-situ reaction monitoring under synthetically relevant conditions. The process is further streamlined by iC Kinetics software that automates the math and provides powerful visualizations to guide scientists to an understanding of reaction mechanisms and the selection of optimal reaction conditions.

How is monitoring your chemical process in real-time like driving with your eyes open?


Oops, I should have seen that coming...

When you run a chemical reaction, a process, an experiment… it is probably critical to you that you do it well – otherwise you wouldn’t waste your time, right?

It’s like buying a car, spending money on gas, taking the wheel and spending your time trying to get to somewhere you need to be. Now, monitoring the reaction in real time is like driving with your eyes opened: you want to know in real time what’s going on in order to be able to take preventive measures and corrective actions (turn, brake, speed up, stop…) and hopefully prevent a car crash that would waste your money, your time, and possibly hurt yourself and your family.

In the driving world, sampling for offline reaction analysis would be like driving with your eyes closed, opening them only once in a while… only to look at a picture of the road a few minutes before… (Yes, it typically takes time to run an analysis and get the results after you’ve taken a sample.)

Who would dare to drive like this? Why would you monitor a chemical process this way then – especially when the chemical process is no less dangerous, and there are options available to “see” exactly where you are and where you are headed? You take the risk of wasting your time, your money, and possibly hurting yourself and your co-workers.

To learn more about METTLER TOLEDO and the ability to “see” your chemical reactions in real-time, please visit our reaction analysis website.

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Pfizer YouTube video: Process Analytical Technology – Using Mid-IR spectroscopy to monitor a telescoped chemical reaction

Ian Clegg, an Associate Research Fellow at Pfizer Global Research and Development Sandwich Laboratories, United Kingdom recently posted a discussion on LinkedIn’s Process Analytical Technology (PAT) group site titled “PAT data (Mid-IR) posted onto YouTube.”

This YouTube video is entitled “Process Analytical Technology: Using Mid-IR spectroscopy to monitor a telescoped chemical reaction.”


In this video, 3 sequential chemical reactions are run in one vessel without stopping or isolating between reactions, and ReactIR™ (real-time in situ reaction analysis) is used to monitor all 3 reaction phases. All of the key reagents, intermediates and products produce unique peaks which show reaction progression without having to take samples. The video shows the spectra of the reaction as a function of time and how the spectra change. The video shows clearly which peaks were monitored and to which components those peaks correlate.

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