Tag Archives: reaction calorimetry

Reaction Calorimetry For Safe Process Scale-up

httpv://www.youtube.com/watch?v=zsEdnQYuV1c
Reaction calorimetry provides information quickly which can be applied to quantify the risks and criticality associated with a chemical process. Reaction calorimetry helps identify key process parameters, including: Continue reading

VisiMix Conference: Influence of Mixing in Your Process

Last week, I attended the VisiMix International Conference in Boston, MA.  Held at the Colonnade Hotel, the conference focused on the influence of mixing unit operations in your process and featured presentations by well-respected leaders in the chemical and pharmaceutical industries on topics including: Continue reading

NESACS’s Bench to Plant Symposium

NESACS SymposiumUpon returning to the Boston area after a number of years away, I was very much looking forward to attending The Northeastern Section of the American Chemical Society (NESACS)’s Advances in Chemical Sciences “Bench to Plant” Symposium for the first time.  Held in Cambridge on October 22, about 100 scientists from the local area gathered for the one day Symposium focusing on Process R&D Chemistry, Organic Synthesis, and New Synthetic Methodology.

Some highlights of the top-notch presentations included:

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Symposium on Process Safety and Crystallization

On Tuesday, November 2, METTLER TOLEDO held its 1st Symposium in Cambridge, MA, hosted by Novartis Institutes for BioMedical Research (NIBR). The success of the Symposium went beyond expectations: 65 scientists representing a large variety of small companies (CoNCERT, Cubist, Tetraphase), larger companies (Pfizer, Dow, Amgen), and research institutions (Massachusetts Institute of Technology) attended the event. The main themes of the Symposium were crystallization and process safety. Des O’Grady and I started by giving an overview of the technologies later covered by the industry speakers: Focused Beam Reflectance Measurement (FBRM®), Particle Video Microscope (PVM®), EasyMax™, RC1, and ReactIR™. Continue reading

Process Development at AIChE 2010

While reviewing the agenda for next month’s American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed a number of papers and posters discussing process development in pharmaceuticals, chemicals, and academia: Continue reading

Fundamentals of Process Scale-Up

On November 25 and November 26, Dr. Reinaldo (Ray) Machado of rm2 technologies will conduct a two-day Fundamentals of Scale-up Workshop.  This advanced process scale-up training will be held at the Ramada Powai in Mumbai, India. Continue reading

Chilworth’s Safe Scale-up of Chemical Processes

safe-scale-up-chemical-processes-webinar

Safe Scale-up of Chemical Processes

On July 1, Dr. Stephen Rowe of Chilworth Technology will present Safe Scale-up of Chemical Processes: Holistic Strategies Supported by Modern Tools.

This online process safety seminar will focus on the overall safety strategy and outlines:

How Process Optimization Cut High Chemical Production Costs

Due to the interest on the recent post on how a major dye and chemical company improved process safety and shortened downtime through process modification, this post will discuss how a major specialty chemicals manufacturer used process optimization to:

  • Cut solvent consumption by 50%
  • Decrease production costs by 10%
  • Reduce batch time from 10 hours to 4 hours

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How Hexion Specialty Chemicals Reduced R&D Expenses

The Challenge: Reaction Calorimetry Under Difficult Conditions
“Unfortunately, our highly exotherm reactions are not always easy to handle”, says Günter Reinsch, head of process optimization and safety at Hexion™ Specialty Chemicals. Continue reading

Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading