For a more detailed look at RPKA, check out this Free On-Demand Webinar (presented by Prof. Donna Blackmond): Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions.
The Reaction Progress Kinetic Analysis (RPKA) Methodology, pioneered by Prof. Donna G. Blackmond of The Scripps Research Institute, requires far fewer reaction progress experiments than the classic kinetics approach. It accomplishes this by exploiting the extensive data available from accurate in-situ reaction monitoring under synthetically relevant conditions. The process is further streamlined by iC Kinetics software that automates the math and provides powerful visualizations to guide scientists to an understanding of reaction mechanisms and the selection of optimal reaction conditions.
Last Thursday, May 6th, I attended the ISPE (International Society for Pharmaceutical Engineering) New England Chapter Biopharma 2010 Conference held in Warwick, Rhode Island. A presentation was given by Geraldine Taber, Pfizer’s Global Technology Group Leader titled “Demise of the Round-Bottomed Flask – How new Battle Tools in the Lab of the Future are delivering value for R&D”.
When you run a chemical reaction, a process, an experiment… it is probably critical to you that you do it well – otherwise you wouldn’t waste your time, right?
It’s like buying a car, spending money on gas, taking the wheel and spending your time trying to get to somewhere you need to be. Now, monitoring the reaction in real time is like driving with your eyes opened: you want to know in real time what’s going on in order to be able to take preventive measures and corrective actions (turn, brake, speed up, stop…) and hopefully prevent a car crash that would waste your money, your time, and possibly hurt yourself and your family.
In the driving world, sampling for offline reaction analysis would be like driving with your eyes closed, opening them only once in a while… only to look at a picture of the road a few minutes before… (Yes, it typically takes time to run an analysis and get the results after you’ve taken a sample.)
Who would dare to drive like this? Why would you monitor a chemical process this way then – especially when the chemical process is no less dangerous, and there are options available to “see” exactly where you are and where you are headed? You take the risk of wasting your time, your money, and possibly hurting yourself and your co-workers.
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Ian Clegg, an Associate Research Fellow at Pfizer Global Research and Development Sandwich Laboratories, United Kingdom recently posted a discussion on LinkedIn’s Process Analytical Technology (PAT) group site titled “PAT data (Mid-IR) posted onto YouTube.”
This YouTube video is entitled “Process Analytical Technology: Using Mid-IR spectroscopy to monitor a telescoped chemical reaction.”
In this video, 3 sequential chemical reactions are run in one vessel without stopping or isolating between reactions, and ReactIR™ (real-time in situ reaction analysis) is used to monitor all 3 reaction phases. All of the key reagents, intermediates and products produce unique peaks which show reaction progression without having to take samples. The video shows the spectra of the reaction as a function of time and how the spectra change. The video shows clearly which peaks were monitored and to which components those peaks correlate.