Tag Archives: processes

How To Develop More Robust Crystallization Processes

Crystallization and precipitation are critical processing steps in chemical development. They can serve as purification and separation steps, and have implications on the yield, purity and particle size distribution. Even though crystallization has advanced significantly over the past decade, many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ. Due to the complexity of crystallization, a process may be developed simply by crashing solids out of solution and transferring a non-robust process with inconsistencies in the yield, purity and particle size distribution. Continue reading

Designing Effective and Efficient Crystallization Processes

This is the sixth blog post in a special series dedicated to crystallization.  In case you missed the previous posts in the series, they are available here:

Previously, we looked at a case study that neatly illustrated the concept that slow supersaturation generation often results in a growth dominated process that is typically repeatable. As a rule of thumb, slow cooling works great – but its main drawback is the extended cycle times that often result. To overcome this problem, a common technique often used is non-linear cooling.

If we dive a little bit deeper into the governing equations of crystal growth and nucleation.. Continue reading

Crystallization Processes in Polymer-Based Materials – Call For Papers

While browsing through the LinkedIn Crystallization Community yesterday, I noticed a discussion started by Mircea Chipara indicating that the Journal of Materials Science is accepting contributions on the topic of Crystallization Processes in Polymer-Based Materials. Continue reading