Tag Archives: process scale-up

Optimization of Highly Reactive Chemistry – Reducing Risks

Highly reactive chemistry is the generic term referring to chemical reactions that pose a challenge due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. Highly reactive chemistries include Grignard, acid chloride, azide, halogenation, and hydrogenation.  Continue reading

VisiMix Conference: Influence of Mixing in Your Process

Last week, I attended the VisiMix International Conference in Boston, MA.  Held at the Colonnade Hotel, the conference focused on the influence of mixing unit operations in your process and featured presentations by well-respected leaders in the chemical and pharmaceutical industries on topics including: Continue reading

Process Development Conference, Weggis, Switzerland

I am happy to announce that the 18th International Process Development Conference (IPDC) will be held September 25 to September 29, 2011 in Weggis, Switzerland.  This year’s conference will focus on workflows from compound development to manufacturing in the pharmaceutical, fine and specialty chemical industries: Continue reading

How To Monitor Biocatalysis in Real Time

This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.

Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading

Fundamentals of Process Scale-Up

On November 25 and November 26, Dr. Reinaldo (Ray) Machado of rm2 technologies will conduct a two-day Fundamentals of Scale-up Workshop.  This advanced process scale-up training will be held at the Ramada Powai in Mumbai, India. Continue reading

AIChE 2010 – Analytical and Optimization Tools in Pilot Plants Session

Among the presentations in the Advanced On-Line Analytical and Optimization Tools in Pilots Plants Session at the 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting will be the New Developments in Heat Transfer Scale Down and In Situ FT-IR Scale-up From the Lab to the Plant.  The presentation, which will be given by Leen Schellekens, will include the challenges that Chemical Engineers face in the chemical and pharmaceutical industries, including globalization, environmental and safety regulations, and shortening product life cycles and the ever increasing time pressure for commercial releases.
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The Three Little Chemists: A Story About Tr-Tj

Three Little Pigs Tr Tj StoryFor years, we have been discussing the value of the Tr-Tj expression (Tr = reaction temperature, Tj = heating/cooling jacket temperature). The ease of use and the valuable insight gained into chemistry from the Tr-Tj expression has already been leveraged by chemists around the world. Since I feel that there are more chemists out there who would benefit from the use of Tr-Tj on a regular basis, I thought I would tell a story to illustrate the value of the Tr-Tj expression. Continue reading

How To Overcome Process Scale-Up Challenges Using Process Analytical Technology (PAT)

Process Analytical Technology for Scale-up

Process Analytical Technology

During Part I of his two part The Role of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering online seminar series, Dominique Hebrault discussed scale-up challenges faced today by chemists and engineers.  Too often, offline sampling methods – mostly chromatographic methods such as High Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC) – are used to monitor processes which fail to resolve common issues like reaction monitoring, poor mass balance, delayed initiation/reaction stalled, and loss of yield/by-products.  From a reaction engineering standpoint, obtaining heat mass balance information and preliminary kinetic data can be difficult using traditional offline methods during process scale-up.  Forming the final solid can be challenging using traditional offline methods, including filtration/drying a bottleneck, excessive washing, polymorph inconsistency, and batch to batch variability can be difficult.
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17th International Process Development Conference – registration is open

mettler-toledo-process-development-conference-ipdc
The 17th International Process Development Conference will be held in Baltimore, Maryland, USA from May 16-19, 2010.

The International Process Development Conference (IPDC) is an annual meeting, hosted by METTLER TOLEDO, which brings together industrial and academic researchers focused on chemical and pharmaceutical process research, scale-up, and manufacturing.

Past conferences have received extremely high marks for the value of the information shared by industry and the quality networking opportunities. Registration discounts are available for university researchers and for users of METTLER TOLEDO automated lab reactors and process analytical technologies.

Conference agenda will include sessions on:

  • Chemical Process Research
  • Crystallization
  • Process Safety & Process Scale-up
  • Process Analytical Technology (PAT) and Quality by Design (QbD)
  • Continuous Processing
  • Emerging Research with Controlled Reactors and Process Analytics
  • For more information

    Registration form