Tag Archives: Process Optimization

How to Use a Crystallization Workstation to Optimize Space for Process Understanding

During crystallization development, chemists often produce crystals rapidly without time for a full Design of Experiment (DoE).  Continue reading

Improve Organic Synthesis in 4 Ways

After writing last week regarding recent advances to improve chemical development in the pharmaceutical industry, there were a lot of discussions about the top 4 ways to improve organic synthesis. Continue reading

How Process Optimization Cut High Chemical Production Costs

Due to the interest on the recent post on how a major dye and chemical company improved process safety and shortened downtime through process modification, this post will discuss how a major specialty chemicals manufacturer used process optimization to:

  • Cut solvent consumption by 50%
  • Decrease production costs by 10%
  • Reduce batch time from 10 hours to 4 hours

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How Hexion Specialty Chemicals Reduced R&D Expenses

The Challenge: Reaction Calorimetry Under Difficult Conditions
“Unfortunately, our highly exotherm reactions are not always easy to handle”, says Günter Reinsch, head of process optimization and safety at Hexion™ Specialty Chemicals. Continue reading

Roller Compaction Process Optimization Using At Line Particle Characterization

roller-compaction-dry-granulation-FBRM-C35-METTLER-TOLEDO

METTLER TOLEDO C35 FBRM probe monitors roller compaction in real time

A successful process based on roller compaction followed by milling should produce a granule with consistent particle size distribution, density, and porosity control. Inconsistencies often occur during granulation scale-up due to changing raw materials or changing process dynamics.
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