Tag Archives: Paul Scholl

近来ACS杂志里列举原位FTIR使用的化学研究

在2010 年即将过去之际,我将于利用十一月十七日的机会再一次回顾实时原位FTIR在促进学术界化学研究中起的作用。这次网络研讨会是一个系列里的第六部:学术界通过使用实时原位FTIR在有机化学研究上的新进展。在准备此研讨会的过程中,我意识到了原位中红外(in situ mid-IR)的使用是如何地广泛,涉及宽广的化学领域。为了方便起见,我把注意力集中在美国化学学会(ACS)杂志的研究文章上。

从2010年起,美国化学学会(ACS)杂志上发表了28篇列举ReactIR™使用的研究文章 (作为本博客的读者,我设想你们多数都知道ReactIR™ 是一个用中红外光谱专门开发出来进行实时原位分析的专用系统) 。这些文章发表在ACS杂志的Macromolecules, Inorganic Chemistry, JACS, Organometallics, JOC, Organic Letters, 和 Analytical Chemistry。另外, 有两本书的章节里列举了ReactIR™。同时,我注意到三分之一的文章发表在ACS 杂志的Macromolecules 和 Inorganic Chemistry上。

在这即将到来的网络研讨会中,我将通过六篇选出的文章回顾ReactIR™在提供化学洞察力上的作用,从而示范说明原位FTIR 的广泛应用。这些文章出自以下化学研究组:

  • Donald Darensbourg (Texas A&M University)
  • Bernard Rieger (Technical University of Munich, Germany)
  • Ming-Hsi Chiang (Academia Sinica, Tapei, Taiwan)
  • Jason Kingsbury (Boston College)
  • Clark Landis (University of Wisconsin-Madison)
  • David MacMillon (Princeton University)

这六篇文章都发表在2010年里。

我希望你会抽时间参加这一2010年最后的学术界通过使用实时原位FTIR在有机化学研究上的新进展网络研讨会。与通常一样,注册参加者将会得到可重播我的十一月十七日实况演讲的许可。

Recent Chemistry Research from ACS Journals Citing Use of In Situ FTIR

As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR.  In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines.  For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.

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如何在现实反应条件下进行化学研究

使用像高压液相色谱(HPLC)、核磁共振(NMR)、和气相色谱(GC)这些传统离线方法来分析化学反应有一个共同的问题:当分析样品从反应体系里取出之后,样品的成分或性质很可能已不代表反应体系里的真实状况,因而导致明显的分析误差。原位傅立叶变换红外(FTIR)分析是解决这种问题的方法。使用原位FTIR分析来在反应器中的现实条件下进行化学研究是理想的,因为它避免传统取样分析法带来的时间滞后和各种误差。

用ReactIR实时原位分析化学反应今天,我想回答一个常提出的问题:

为何用原位FTIR分析取代离线分析方法进行化学反应分析?

  • 一个实际存在的关键的中间产物在离线样品里可能已经消失了
  • 取样时不小心或不可避免引入的空气可以改变化学条件
  • 因反应毒性之高需要防止接触反应体系
  • 反应在高压和/或极高温度下进行 — 取样可能改变化学成份,致使分析不合格

原位FTIR分析可用于分析几乎所有化学反应,包括:

  • 腐蚀性化学反应
  • 高温高压反应
  • 固液多项反应体系
  • 带水或有机溶剂的反应体系
  • 酸性或碱性反应体系

十一月十七日, Paul Scholl 将在“学术界在有机化学方面使用实时原位FTIR的新进展”网络研讨会中更具体地讲解本论题。Paul会谈论以下领域里近来发表的使用原位FTIR分析来更好地理解化学反应的案例: 有机合成、催化、金属有机、高分子合成、及反应动力学。

How To Study Chemistry Under Actual Reaction Conditions

Traditional offline methods to analyze reaction chemistry, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC), share a common problem: when a sample is removed for analysis, it may be altered or compromised resulting in significant analytical errors. The solution for this is Continue reading

How Real-Time In Situ FTIR Advances Organic Chemistry

Advances in Organic Chemistry in Academia

Recent Advances in Organic Chemistry

Paul Scholl will present a free online seminar – Recent Advances in Organic Chemistry in Academia Using Real-Time In Situ FTIR – on July 28.  This on-going series reviews recent advances in organic chemistry by academia where real-time in situ mid-infrared (mid-IR) analytics played a role in the advancement of organic chemistry research.

During the Recent Advances in Organic Chemistry seminar, Paul will discuss several recent publications by academia illustrating how real-time in situ Fourier Transform Infrared spectroscopy (FTIR) was used to help advance the fundamental understanding of organic chemistry. During this series, the following research areas have been discussed:
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An Easier Way to Complete Polymer Research Experiments in Academia

University of North Carolina 2010 National Graduate Research Polymer ConferenceThis past week, I attended the National Graduate Research Polymer Conference (NGRPC), which was hosted by the University of North Carolina at Chapel Hill Department of Chemistry.  A well known polymer chemist and professor from another large state university commented without any prompting from me that he really would like to change from using round bottom flasks to using the EasyMax™ for their polymer syntheses.  I saw this as a good opportunity to learn from his perspective what he felt the inherent value was of the EasyMax™, an automated lab reactor system, in academia.

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The Future of Chemical Research and Development: The Demise of the Round Bottomed Flask

ISPE-New-England-Chapter-BioPharma-ConferenceLast Thursday, May 6th, I attended the ISPE (International Society for Pharmaceutical Engineering) New England Chapter Biopharma 2010 Conference held in Warwick, Rhode Island.  A presentation was given by Geraldine Taber, Pfizer’s Global Technology Group Leader titled “Demise of the Round-Bottomed Flask – How new Battle Tools in the Lab of the Future are delivering value for R&D”.

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Pfizer YouTube video: Process Analytical Technology – Using Mid-IR spectroscopy to monitor a telescoped chemical reaction

Ian Clegg, an Associate Research Fellow at Pfizer Global Research and Development Sandwich Laboratories, United Kingdom recently posted a discussion on LinkedIn’s Process Analytical Technology (PAT) group site titled “PAT data (Mid-IR) posted onto YouTube.”

This YouTube video is entitled “Process Analytical Technology: Using Mid-IR spectroscopy to monitor a telescoped chemical reaction.”

httpv://www.youtube.com/watch?v=EWec0O6WtUU

In this video, 3 sequential chemical reactions are run in one vessel without stopping or isolating between reactions, and ReactIR™ (real-time in situ reaction analysis) is used to monitor all 3 reaction phases. All of the key reagents, intermediates and products produce unique peaks which show reaction progression without having to take samples. The video shows the spectra of the reaction as a function of time and how the spectra change. The video shows clearly which peaks were monitored and to which components those peaks correlate.

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