Tag Archives: PAT for crystallization

BIWIC 2010: Optimization & Scale-up of Anti-Solvent Crystallization

Later this week, scientists and engineers will join together at Martin Luther University Halle-Wittenberg in Germany for the BIWIC 2010 – International Workshop on Industrial Crystallization.  Topics at this year’s International Workshop on Industrial Crystallization will include fundamentals of crystallization (thermodynamics and kinetics), process design (monitoring and modeling), product design (polymorphism, salvation, stability, chiral separation, fine chemicals, pharmaceuticals), industrial applications, and intensified processes and equipment (external fields, micro technology, hybrid processes). Continue reading

Implications of a Well-Designed Crystallization Process

well-designed crystallization processCrystallization is a critical process for the purification and isolation of chemical compounds in the manufacture of many fine chemical and pharmaceutical products. The results of the crystallization step have far reaching impacts on overall process efficiency and final product quality. Crystallization is also a very difficult process to effectively optimize and control. Crystallization is inherently complicated simply by being a process involving the creation and formation of solid particles.

Timothy A. Bell, of DuPont Engineering Research and Technology, wrote a review of the challenges of scaling-up particulate processes where he stated: Continue reading