Tag Archives: particle system characterization

YouTube Video: PowTech/TechnoPharm 2010 Innovation Award for METTLER TOLEDO FBRM C35

Earlier I posted that the METTLER TOLEDO Particle System Characterization group won an Innovation Award at the PowTech/TechnoPharm 2010 Exhibition for their FBRM C35 product for real-time monitoring of high-shear granulation and other challenging particulate processes.

In this video, Carl Phillip, Business Area Manager for Particle System Characterization, gives a short interview explaining why they earned the Innovation Award:


Real-time Particle Measurement: In Situ Measurements of Gas Fluidized Nanoagglomerates


Figure 5 b) Agglomerate size distributions of Aerosil R974 in conventional and jet assisted fluidized beds.

A paper by Jose Quevedo and Robert Pfeffer titled In Situ Measurements of Gas Fluidized Nanoagglomerates was just published on the web and will also be published in an upcoming issue of Industrial & Engineering Chemical Research.

The paper explores the in-process measurement of nanoparticle aggregates in a fluidized bed. Real-time, in-process particle system measurement with FBRM (Focused Beam Reflectance Measurement) and PVM (Particle Video Microscopy) show significant differences in the density and mean size of the aggregates formed in conventional fluid beds and microjet assisted fluid bed.

The authors report:

“Nanoparticles cannot be fluidized as individual particles but instead fluidize in the form of large (mean size about 100-400 μm), highly porous (internal porosity greater than 98%), hierarchical fractal structured agglomerates. Many nanopowders are very difficult to fluidize because of the large cohesive forces between the particles due to their very small size and high surface area…

In situ agglomerate size measurements and imaging of fluidized nanoagglomerates were achieved by reducing the electrostatic charge in the bed and using the FBRM and PVM probes from Lasentec.”

Electrostatic charges were reduced by bubbling the fluidizing gas through an alcohol-water mixture. This dramatically reduced adhesion of particles to surfaces and greatly improved the quality of the on-line measurements in this dry fluidized bed.


In Situ Measurements of Gas Fluidized Nanoagglomerates
Jose A. Quevedo† and Robert Pfeffer*‡
Otto York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102
Ind. Eng. Chem. Res., Article ASAP
DOI: 10.1021/ie9015446
Publication Date (Web): March 2, 2010

Publication is Copyright © 2010 American Chemical Society
† Current address: Shell Global Solutions, P.O. Box 38000, 1030BN Amsterdam, The Netherlands.
‡ Current address: Department of Chemical Engineering, Arizona State University, Tempe, AZ 85287.

Process Analytical Technology (PAT) in Fermentation

Here are citations from papers that discuss Process Analytical Technology (PAT) in Fermentation as it specifically relates to biomass monitoring using real-time particle system characterization: Continue reading

Understanding Dissolution Inconsistency Through In Situ Particle Characterization and Root Cause Analysis


METTLER TOLEDO FBRM and Opt Diss Fiber Optic UV for Dissolution Testing in Distek Evolution 6100

USP tablet dissolution testing is recognized as the standard analytical method used in the pharmaceutical industry.

Traditionally, dissolution has been performed in the analytical laboratory and tests were conducted with the final product. But in recent years dissolution testing has become a development tool for Quality by Design (QbD), and testing has expanded to include dissolution and disintegration tests which screen product performance during drug product development.
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Roller Compaction Process Optimization Using At Line Particle Characterization


METTLER TOLEDO C35 FBRM probe monitors roller compaction in real time

A successful process based on roller compaction followed by milling should produce a granule with consistent particle size distribution, density, and porosity control. Inconsistencies often occur during granulation scale-up due to changing raw materials or changing process dynamics.
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Optimization and Scale-up of High Shear Wet Granulation Processes


FBRM® C35 with mechanical wiper for in situ granulation measurement

One goal of high shear granulation is to yield repeatable endpoint granule size, shape, and density distributions. This is necessary for consistent downstream flow properties, tablet consistency, and content uniformity. Quality by Design (QbD) is a concept applied to gain true process understanding through tools such as Design of Experiment (DoE), risk management, and Process Analytical Technology (PAT).

This extended abstract summarizes collaborative research between GlaxoSmithKline (GSK) and METTLER TOLEDO in the application of process analytical technologies (PAT) to the monitoring, optimization and control of High Shear Wet Granulation.

Download the extended abstract for this upcoming conference presentation.

Zane Arp, GSK
Eric Dycus, Ben Smith, METTLER TOLEDO
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Real-time monitoring of polymer growth kinetics using METTLER TOLEDO FBRM and PVM

Wiley InterScience highlighted a paper that was just published in MacroMolecular Reaction Engineering by Professor Rolf Mülhaupt and his student Rainer Xalter of Albert-Ludwigs University in Freiburg, Germany.

This paper discusses the use of METTLER TOLEDO FBRM® and PVM® for real-time in-process monitoring of polymer and catalyst particles. During the polymerization of high-density polyethylene (HDPE), FBRM® and PVM® are used to determine polymer growth kinetics and to measure the effects of catalyst breakage and attrition within standard commercial-scale reactors.

“Unprecedented insight into the particle growth processes during ethylene slurry polymerizations catalyzed by supported single-site and Ziegler catalysts was gained by online monitoring using two different probes inserted directly into the reactor. FBRM online monitoring complemented by PVM online visualization of polymer particles allowed for the distinction of different types of particle growth processes depending on catalyst type and productivity.”

Citation: “On-line Monitoring of Polyolefin Particle Growth in Catalytic Olefin Slurry Polymerization by means of LasentecTM Focused Beam Reflectance Measurement (FBRM) and Video Microscopy (PVM) Probes”, R. Xalter and R. Mülhaupt, Macromol. React. Eng. 2010, 4, 25. http://doi.wiley.com/10.1002/mren.200900048?crel=US_AC_eAdv_Blog


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