Tag Archives: particle size distribution

Polymorph Form Control: Why Care About Seeding and Cooling Rates?

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Mark Barrett and others at the University College Dublin (UCD) recently published a paper Continue reading

How To Optimize Crystal Size Distribution, Improve Filtration Rates, and Batch Consistency

httpv://www.youtube.com/watch?v=5VeCg6LQSYY

Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Continue reading

How To Develop More Robust Crystallization Processes

Crystallization and precipitation are critical processing steps in chemical development. They can serve as purification and separation steps, and have implications on the yield, purity and particle size distribution. Even though crystallization has advanced significantly over the past decade, many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ. Due to the complexity of crystallization, a process may be developed simply by crashing solids out of solution and transferring a non-robust process with inconsistencies in the yield, purity and particle size distribution. Continue reading

Introduction to Crystallization & Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture. Salt and sugar are delivered to our dinner tables as crystals. The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

Inline Particle Size, Shape & Count History: Lasentec® FBRM®

particle size Lasentec FBRM

For over 25 years, FBRM® technology has been used for real-time monitoring of particles and droplets as they naturally exist in process.   Continue reading

Particle Size Distribution, Particle Shape, and Particle Count – Track Changes

Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO.  It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!

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High Resolution, Fast Understanding, Intuitive Particle Measurement

Inline particle size measurement technology is used to quickly:

  • Understand the particle system’s response when changing process parameters
  • Optimize the particle system to improve process performance and product quality
  • Control the particle system to achieve consistent particle size distribution endpoints, batch repeatability, and process stability Continue reading

Introduction to Crystallization and Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture.  Salt and sugar are delivered to our dinner tables as crystals.  The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

2010 AAPS Annual Meeting – Highlights

American Association of Pharmaceutical Scientists (AAPS) MeetingThis week, I was in New Orleans attending the 2010 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting. The AAPS Meeting combines a large trade show with technical presentation and poster sessions running in parallel.

At the 2010 AAPS meeting, hot topics included Quality by Design (QbD), Process Analytical Technology (PAT) and the drive towards real-time release for pharmaceutical products. FBRM and PVM technologies were well represented with numerous posters and presentations focusing on their use to understand, optimize and control particle size distribution during drug product formulation. Continue reading

Predicting Dissolution Quality With Fluid Bed Granulation

Last month, Steve Mehrman of Johnson & Johnson gave a presentation on using Fluid Bed Granulation as a predictor of dissolution performanceContinue reading