Tag Archives: Organic Process Research & Development

4th Annual Uniqsis Flow Chemistry Symposium

Uniqsis British ConsulateBy no means am I a flow chemistry expert, but as probably the case for many other chemists, continuous processing has piqued my interest over the past few years. Continue reading

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

reactir-flow-cell-oprd
Developments in continuous flow chemistry: an article by Professor Steven Ley of Cambridge University was just published on the OPRD (ACS) website.

Citation:

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing.
Catherine F. Carter†, Heiko Lange†, Steven V. Ley*†, Ian R. Baxendale†, Brian Wittkamp‡, Jon G. Goode§ and Nigel L. Gaunt§

† Innovative Technology Centre, University of Cambridge.
, ‡ Mettler-Toledo AutoChem, U.S.A.
, § Mettler-Toledo AutoChem, UK.

Org. Process Res. Dev., Article ASAP
DOI: 10.1021/op900305v
Publication Date (Web): February 1, 2010
Copyright © 2010 American Chemical Society

Process Analytical Technology (PAT) for BioCatalysis

Below are citations from interesting papers that discuss Process Analytical Technology (PAT) for BioCatalysis, highlighting faster development and optimization of scalable processes: Continue reading

Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading