By no means am I a flow chemistry expert, but as probably the case for many other chemists, continuous processing has piqued my interest over the past few years. Continue reading
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing.
Catherine F. Carter†, Heiko Lange†, Steven V. Ley*†, Ian R. Baxendale†, Brian Wittkamp‡, Jon G. Goode§ and Nigel L. Gaunt§
† Innovative Technology Centre, University of Cambridge.
, ‡ Mettler-Toledo AutoChem, U.S.A.
, § Mettler-Toledo AutoChem, UK.
Org. Process Res. Dev., Article ASAP
Publication Date (Web): February 1, 2010
Copyright © 2010 American Chemical Society
Below are citations from interesting papers that discuss Process Analytical Technology (PAT) for BioCatalysis, highlighting faster development and optimization of scalable processes: Continue reading
Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject: “Precaution during scale-up of a Grignard reaction?”. This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading