A classified area mid-infrared analyzer designed for outdoor use will typically have a temperature range where it can operate without additional sheltering. Continue reading
As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR. In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines. For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.
In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration
Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading
While reviewing the agenda for next month’s American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed a number of papers and posters discussing process development in pharmaceuticals, chemicals, and academia: Continue reading
Paul Scholl will present a free online seminar – Recent Advances in Organic Chemistry in Academia Using Real-Time In Situ FTIR – on July 28. This on-going series reviews recent advances in organic chemistry by academia where real-time in situ mid-infrared (mid-IR) analytics played a role in the advancement of organic chemistry research.
During the Recent Advances in Organic Chemistry seminar, Paul will discuss several recent publications by academia illustrating how real-time in situ Fourier Transform Infrared spectroscopy (FTIR) was used to help advance the fundamental understanding of organic chemistry. During this series, the following research areas have been discussed:
Ian Clegg, an Associate Research Fellow at Pfizer Global Research and Development Sandwich Laboratories, United Kingdom recently posted a discussion on LinkedIn’s Process Analytical Technology (PAT) group site titled “PAT data (Mid-IR) posted onto YouTube.”
This YouTube video is entitled “Process Analytical Technology: Using Mid-IR spectroscopy to monitor a telescoped chemical reaction.”
In this video, 3 sequential chemical reactions are run in one vessel without stopping or isolating between reactions, and ReactIR™ (real-time in situ reaction analysis) is used to monitor all 3 reaction phases. All of the key reagents, intermediates and products produce unique peaks which show reaction progression without having to take samples. The video shows the spectra of the reaction as a function of time and how the spectra change. The video shows clearly which peaks were monitored and to which components those peaks correlate.
The on-demand version of the Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool webinar that I presented on January 20 is now available.
During this on-demand webinar, I review case studies from the pharmaceutical industry to show how real-time mid-infrared (mid-IR) analytics provide critical information that results in shorter process development timelines, including:
- Intermediate detection during an indazole alkylation and scale-up – Pfizer
- Hazardous gas detection during tetrazole synthesis – Merck
- Monitoring a Grignard reaction at the multikilogram scale – Bristol-Myers Squibb
- Scale-up involving a sensitive enolate – Johnson and Johnson (J&J)
If you have any questions or would like to discuss this further, then please contact me.