Tag Archives: mettler toledo blog

Process Development at AIChE 2010

While reviewing the agenda for next month’s American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed a number of papers and posters discussing process development in pharmaceuticals, chemicals, and academia: Continue reading

Use of Process Analytical Technology (PAT) for Biotech

Process Analytical Technology (PAT) for Biotech: A Review of Recently Reported Applications in Fermentation and BioProcessing

Fermentation and bioprocessing play critical roles in the discovery and manufacture of new pharmaceuticals and specialty chemicals, and in the sustainable production of bulk fuels and commodity chemicals. Yet fermentation processes are often operated with a minimal level of monitoring and control, limiting the ability to optimize yields and production rates. Continue reading

Fundamentals of Process Scale-Up

On November 25 and November 26, Dr. Reinaldo (Ray) Machado of rm2 technologies will conduct a two-day Fundamentals of Scale-up Workshop.  This advanced process scale-up training will be held at the Ramada Powai in Mumbai, India. Continue reading

Crystallization at the AIChE 2010 Annual Meeting

While reviewing the technical program for the upcoming 2010 American Institute of Chemical Engineers (AIChE) Annual Meeting, I noticed several papers of interest to those of us who work in crystallization: Continue reading

Chemical Process Development Symposium at Novartis

Cambridge, Massachusetts is a unique place due to having one of the largest (per capita) and most impressive populations of scientists and engineers in the world.  Because of this, Cambridge is recognized as a global hub for biotechnology.  This makes the Boston area an attractive venue to organize a chemical process development gathering. Continue reading

Predicting Dissolution Quality With Fluid Bed Granulation

Last month, Steve Mehrman of Johnson & Johnson gave a presentation on using Fluid Bed Granulation as a predictor of dissolution performanceContinue reading

How To Study Chemistry Under Actual Reaction Conditions

Traditional offline methods to analyze reaction chemistry, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC), share a common problem: when a sample is removed for analysis, it may be altered or compromised resulting in significant analytical errors. The solution for this is Continue reading

Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries

Last week, John Tedesco and I had the privilege to attend the 3rd International Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries in Boston, MA. Continue reading

Optimize Chemistry Via Kinetic Analysis

On October 20, Professor Donna Blackmond will present the second part of a webinar series – Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions. Continue reading

Automating Crystallization Development

On Wednesday, I presented an online seminar: Automating Crystallization Development: Metastable Zone Width Determination and Supersaturation Control, which summarized a two day collaboration with a major pharmaceutical company where crystallization development time was reduced and scale-up efficiency was improved. Continue reading