Tag Archives: mettler toledo blog

4th Annual Uniqsis Flow Chemistry Symposium

Uniqsis British ConsulateBy no means am I a flow chemistry expert, but as probably the case for many other chemists, continuous processing has piqued my interest over the past few years. Continue reading

UK Automated Synthesis Forum (UKASF) – Novartis

This week, the United Kingdom Automated Synthesis Forum (UKASF) will be held at Novartis in Horsham.  Ian Clemens of Novartis is the Chair of the UKASF and will deliver the opening remarks to begin the Forum on Wednesday.

The first session, which will be chaired by Steve Brough of AstraZeneca, will be on Flow Chemistry and will include: Continue reading

Recent Chemistry Research from ACS Journals Citing Use of In Situ FTIR

As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR.  In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines.  For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.

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1st Annual RSC/SCI Continuous Flow Symposium

Jon Goode, Nigel Gaunt, and I attended the 1st Annual Royal Society of Chemistry (RSC)/Society of Chemical Industry (SCI) Continuous Flow Symposium held last week at GlaxoSmithKline in Stevenage, United Kingdom.  Considering that this was the first time this particular event was held, it was very well attended.  This was yet another reminder of what seems to be an ever increasing interest in continuous flow. Continue reading

Mary K. O’Connor Process Safety Center 2010 International Symposium

My colleague, Rodrigo Maciel, and I had the opportunity to attend the Mary K. O’Connor Process Safety Center 2010 International Symposium October 26 to 28 at Texas A&M University in College Station, Texas.  This process safety conference had about 400 attendees, which included representation from government agencies (OSHA, Chemical Safety Board), Chemical Engineering Professors from around the globe, Safety Consultants, and Process Safety Managers and Scientists from Petrochemical and Chemical companies.  The event featured 106 presentations and 20 exhibitors. Continue reading

How To Optimize Peptide Synthesis

This is the second blog post in a 2 part series where I discuss the real-time monitoring of bio-based chemical synthesis. Continue reading

How To Monitor Biocatalysis in Real Time

This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.

Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading

Process Analytical Technology (PAT) in Fermentation

In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration

Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading

How To Track Particle Distribution in Real Time: AAPS 2010

The 2010 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting will be held November 14 to 18 in New Orleans.  As thousands of pharmaceutical scientists from around the world prepare to gather for the AAPS conference that is being held in conjunction with the International Pharmaceutical Federation’s (FIP) Pharmaceutical Sciences World Congress (PSWC), I wanted to highlight some papers that will discuss how to track particle distribution in real-time:

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Green Pharmaceutical Manufacturing on a Foundation of PAT & QbD

This is a guest blog post by Paul Thomas.  Paul is Senior Editor of Pharmaceutical Manufacturing magazine, PharmaManufacturing.com, and PharmaQbD.com.

Next week, METTLER TOLEDO is hosting a webcast on using Process Analytical Technology (PAT) and Quality by Design (QbD) for the greening of drug manufacturing operations. I’ll be kicking off the program by discussing the potential of the industry to leverage PAT/QbD to meet corporate sustainability objectives such as reducing energy usage and cutting carbon emissions. It’ll be a big-picture look at the elements of PAT and QbD that overlap with sustainable manufacturing. Continue reading