There are several interesting upcoming crystallization conferences and meetings. Continue reading
This is the third blog post in a series dedicated to crystallization. In case you missed the first and second in the series, they are available here: Introduction to Crystallization and Precipitation and Common Ways to Reduce Solubility and Drive Crystallization.
Supersaturation is the driving force for all solution crystallization processes. Crystallization scientists gain control over crystallization process and product quality by carefully controlling the prevailing level of supersaturation during the process. Continue reading
Later this week, scientists and engineers will join together at Martin Luther University Halle-Wittenberg in Germany for the BIWIC 2010 – International Workshop on Industrial Crystallization. Topics at this year’s International Workshop on Industrial Crystallization will include fundamentals of crystallization (thermodynamics and kinetics), process design (monitoring and modeling), product design (polymorphism, salvation, stability, chiral separation, fine chemicals, pharmaceuticals), industrial applications, and intensified processes and equipment (external fields, micro technology, hybrid processes). Continue reading
In an ideal world, you may want to directly measure the crystal population within the crystallizer (a critical product quality attribute) and measure the supersaturation which is driving the process (a critical process parameter). Today’s advanced Process Analytical Technology (PAT) allows you to measure both of these critical parameters in real time. But where should you begin – especially if budget constraints limit you to implementing only one advanced measurement. Continue reading
1. Reduce fines generation
2. Identify crystallization problems at small scale
3. Optimize seeding protocol
4. Target an appropriate endpoint during wet milling
5. Identify and monitor polymorph transformation
For additional details to improve laboratory crystallization, view the online seminar I presented: Top Five High Impact Ways In Situ Particle Characterization Can Improve Laboratory Crystallization.
If you are interested in discussing crystallization topics with over 400 others who work in crystallization, I encourage you to join the LinkedIn Crystallization Community.
Add your comments below if you have any additional crystallization resources or thoughts you would like to highlight.