Tag Archives: Lasentec

在线分析颗粒大小、形状、及数量的历史:Lasentec® FBRM®

Lasentec History二十五年来, FBRM® 技术一直用于实时监测工艺过程中自然存在的颗粒与液滴。自2001年收购了Lasentec® (Lasentech)之后,梅特勒-托利多不断地改进开发在线颗粒大小、形状、和数量分布的测量技术。目前,已有数千个FBRM® 和PVM® 系统安装在世界各地,从研发实验室到生产厂。

我想人们会有兴趣看看Lasentec®、FBRM® 和PVM® 技术的历史:

2011

新一代 FBRM® (G Series) 上市,在原位颗粒测量的准确性和灵敏度上具有突破性进展。

  • 通过软件对粘贴的颗粒进行校正,从而增强对工艺过程的理解
  • 对颗粒分布的高分辨率提供更准确的信息
  • 可互换的探头配置平台拓宽应用性
  • 增强的探头牢靠度减少维修服务次数

2009

梅特勒-托利多荣获Powtech/TechnoPharm 创新奖 ,奖励其将FBRM®应用于在线成粒过程的开发。

2007

小规模 19毫米直径的具有显微镜质量显像的PVM® ,即使是在高固体浓度下。

2002

8毫米设计直径的小型FBRM、和深入管道安装式FBRM®

2001

梅特勒-托利多收购Lasentec®

2000

19毫米直径压缩空气推动的FBRM®

1996

用于在线颗粒视像和测量的第一个PVM®

1990

第一个基于探头的、实时、原位颗粒特征分析FBRM®

1986

Lasentec® 因其离线FBRM®技术获得“研发一百强奖”(R&D 100 Award

Inline Particle Size, Shape & Count History: Lasentec® FBRM®

particle size Lasentec FBRM

For over 25 years, FBRM® technology has been used for real-time monitoring of particles and droplets as they naturally exist in process.   Continue reading

Particle Size Distribution, Particle Shape, and Particle Count – Track Changes

Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO.  It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!

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怎样实时跟踪颗粒分布:AAPS 2010

2010 美国医药科学家协会(AAPS) 年会 即将于十一月十四至十八日在新奥尔良召开。本届AAPS年会与国际医药联邦(FIP)的医药科学国际协会 (PSWC)携手,将聚集来自全世界的数千医药科学家们。在此,我想点出会议上将要讨论的一些涉及怎样实时跟踪颗粒分布的报告:http://cn.mt.com/cn/zh/home/events/fairs/AAPS_2010.html?=US_AC_eAdv_zhBlog

  • SU9199  用非谱图式在线颗粒分布的确定作为高剪切力湿式成粒的终点;Purdue University, Sunday PM
  • T2124  评价用于高剪切力湿式成粒监测和终点确定的PAT 工具:NIR, FBRM, PVM, ARS Novartis, Tuesday AM
  • T2139  工艺过程分析技术:用FBRMPVM 在线监测PLGA 微米颗粒形成过程;FDA/CDER/OPS/DPQR, Tuesday AM
  • T3070 用高分子来维持溶解差的药物分子在液添胶囊制剂试管溶解时的超饱和机理研究;Amgen, Tuesday PM
  • W4256 实时颗粒分析:用聚光反射测量 (FBRM) 作为工艺过程分析技术 (PAT) Campbell University and GlaxoSmithKline, Wednesday AM
  • W5050  预测高剪切力湿式研磨药物固体的表现; Pfizer, Wednesday PM
  • W5423  质量源于设计 (QbD) 案例研究:寻找实时PAT工艺过程监测与离线产品定性分析之间的关联;FDA/CDER/OPS/DPQR, Wednesday PM
  • W5429  Lasentec FBRM C35 探头用于高剪切力湿式成粒过程中实时测量颗粒玄长分布的分辨率和灵敏度以及与其它颗粒分布技术的对比; Bristol-Myers Squibb (BMS), Wednesday PM
  • W5432  通过原位颗粒和液滴定性分析改进液体制剂; METTLER TOLEDO, Wednesday PM
  • R6266  应用QbD原理评价各种Hypromellose等级以确保可持续放行的制剂工艺;GlaxoSmithKline, Thursday AM

我期待在AAPS年会上见到您,并邀请您参观展示大厅的612展台。

您可能会感兴趣的类似贴文:

How To Track Particle Distribution in Real Time: AAPS 2010

The 2010 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting will be held November 14 to 18 in New Orleans.  As thousands of pharmaceutical scientists from around the world prepare to gather for the AAPS conference that is being held in conjunction with the International Pharmaceutical Federation’s (FIP) Pharmaceutical Sciences World Congress (PSWC), I wanted to highlight some papers that will discuss how to track particle distribution in real-time:

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Real-time Particle Measurement: In Situ Measurements of Gas Fluidized Nanoagglomerates

Gas-Fluidized-Nanoagglomerates-FBRM-METTLER-TOLEDO

Figure 5 b) Agglomerate size distributions of Aerosil R974 in conventional and jet assisted fluidized beds.

A paper by Jose Quevedo and Robert Pfeffer titled In Situ Measurements of Gas Fluidized Nanoagglomerates was just published on the web and will also be published in an upcoming issue of Industrial & Engineering Chemical Research.

The paper explores the in-process measurement of nanoparticle aggregates in a fluidized bed. Real-time, in-process particle system measurement with FBRM (Focused Beam Reflectance Measurement) and PVM (Particle Video Microscopy) show significant differences in the density and mean size of the aggregates formed in conventional fluid beds and microjet assisted fluid bed.

The authors report:

“Nanoparticles cannot be fluidized as individual particles but instead fluidize in the form of large (mean size about 100-400 μm), highly porous (internal porosity greater than 98%), hierarchical fractal structured agglomerates. Many nanopowders are very difficult to fluidize because of the large cohesive forces between the particles due to their very small size and high surface area…

In situ agglomerate size measurements and imaging of fluidized nanoagglomerates were achieved by reducing the electrostatic charge in the bed and using the FBRM and PVM probes from Lasentec.”

Electrostatic charges were reduced by bubbling the fluidizing gas through an alcohol-water mixture. This dramatically reduced adhesion of particles to surfaces and greatly improved the quality of the on-line measurements in this dry fluidized bed.

Citation:

In Situ Measurements of Gas Fluidized Nanoagglomerates
Jose A. Quevedo† and Robert Pfeffer*‡
Otto York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102
Ind. Eng. Chem. Res., Article ASAP
DOI: 10.1021/ie9015446
Publication Date (Web): March 2, 2010

Publication is Copyright © 2010 American Chemical Society
† Current address: Shell Global Solutions, P.O. Box 38000, 1030BN Amsterdam, The Netherlands.
‡ Current address: Department of Chemical Engineering, Arizona State University, Tempe, AZ 85287.

Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes On-Demand Webinar

In case you missed the live webinar, Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes, presented today by Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland, the on-demand version of  Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes is now available.

View the Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes on-demand webinar.

If you are interested in discussing Crystallization topics with Mark Barrett and over 300 others who work in Crystallization, I invite you to join the LinkedIn Crystallization Community.

Optimization and Scale-up of Fluid Bed Processes

Fluid Bed Granulation and Coating from GEA and Niro Pharma SystemsSpray layering is increasingly being used to produce spherical pellets of a target particle distribution – often with engineered dissolution profiles for time-release formulations.

This extended abstract summarizes collaborative research between GEA (Niro) Pharma Systems and METTLER TOLEDO in the application of process analytical technologies (PAT) to the monitoring, optimization and control of Precision Fluid Bed Granulation and Fluid Bed Coating.

Download the extended abstract from the presentation given at the 7th World Meeting on Pharmaceutics, Biopharmaceutics, and Pharmaceutical Technology.

Authors:
Andrew Birkmire, Dr. Kim Walters, GEA (Niro) Pharma
Dr. Mario Hubert, BMS
Eric Dycus, Terry Redman, Ben Smith, METTLER TOLEDO
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Roller Compaction Process Optimization Using At Line Particle Characterization

roller-compaction-dry-granulation-FBRM-C35-METTLER-TOLEDO

METTLER TOLEDO C35 FBRM probe monitors roller compaction in real time

A successful process based on roller compaction followed by milling should produce a granule with consistent particle size distribution, density, and porosity control. Inconsistencies often occur during granulation scale-up due to changing raw materials or changing process dynamics.
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Real-time monitoring of polymer growth kinetics using METTLER TOLEDO FBRM and PVM

polymer-growth-kinetics-FBRM-PVM-METTLER-TOLEDO
Wiley InterScience highlighted a paper that was just published in MacroMolecular Reaction Engineering by Professor Rolf Mülhaupt and his student Rainer Xalter of Albert-Ludwigs University in Freiburg, Germany.

This paper discusses the use of METTLER TOLEDO FBRM® and PVM® for real-time in-process monitoring of polymer and catalyst particles. During the polymerization of high-density polyethylene (HDPE), FBRM® and PVM® are used to determine polymer growth kinetics and to measure the effects of catalyst breakage and attrition within standard commercial-scale reactors.

“Unprecedented insight into the particle growth processes during ethylene slurry polymerizations catalyzed by supported single-site and Ziegler catalysts was gained by online monitoring using two different probes inserted directly into the reactor. FBRM online monitoring complemented by PVM online visualization of polymer particles allowed for the distinction of different types of particle growth processes depending on catalyst type and productivity.”

Citation: “On-line Monitoring of Polyolefin Particle Growth in Catalytic Olefin Slurry Polymerization by means of LasentecTM Focused Beam Reflectance Measurement (FBRM) and Video Microscopy (PVM) Probes”, R. Xalter and R. Mülhaupt, Macromol. React. Eng. 2010, 4, 25. http://doi.wiley.com/10.1002/mren.200900048?crel=US_AC_eAdv_Blog

 

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