Tag Archives: larger scale

Enable Process Analytical Technology Without Modifying or Replacing Reactors

Commitment and investment to develop the use of Process Analytical Technology (PAT) is a primary reason why the pharmaceutical industry is able to find ways to streamline and improve manufacturing processes. However, there are significant challenges when implementing Process Analytical Technology (PAT) into larger-scale manufacturing, such as compatibility of measurement instrumentation with classified hazardous areas and the existing processing infrastructure. Even more important is how to sample the chemistry in situ. The majority of reactor vessels in commission today lack suitable entry points for the measurement technology that requires there modification or replacement, which can significantly increase project costs or prohibit implementation entirely. Continue reading