Tag Archives: GSK

第一届年度RSC/SCI连续流动学术报告会

Jon Goode、Nigel Gaunt和我参加了第一届年度皇家化学学会(RSC)/化学工业学会(SCI)的连续流动学术报告会,该会于十一月初在英国由地处Stevenage的GlaxoSmithKline公司主持。考虑是第一次举办这种特殊报告会,其出席状况非常良好。这也提示我们大家对连续流动的兴趣越来越高。

监测连续流动化学在此学术报告会上,我展示了一个墙报,题为“配备ReactIR™ (FTIR) 测量的连续化学过程”。我讨论了对产品质量、产率、合成途径、安全、和总体时间效率上的改进如何已成为科学家和工程师们寻找化学开发的非传统方法的动力因素。

要确保只生产想要的产物,反应控制很关键,而像带毒性和/或高活性中间体这些副产物可能难以控制进而带给操作人员安全危险。连续流动反应器能使化学反应得到更好的控制,降低生成非理想产物的可能性,并因操作体积很小而显著降低对操作人员的安全危险。

对连续流动反应器进行理想的控制自然需要在线分析技术。离线分析方法只能零散地对控制参数提供反馈(数分钟或数小时的间隔,根据所用分析技术/方法),而在线测量仪每几秒到几分钟提供一反馈。我讨论了为什么与微型流动池相结合的傅立叶变换红外(FTIR)光谱的应用提供一个理想的在线测量装置,用它来对反应的控制参数进行监测和控制反馈,从而达到即时理解和优化其工艺过程。

我的报告用了两个不同的例子(还原反应和羰基化作用)表明连续流动反应器与在线ReactIR™测量技术相结合的应用价值。从这两个例子中搜集的信息演示了这种结合体系的有效性。

如果您有兴趣了解更多有关流动化学的益处,我邀请您参看英国剑桥大学Steven Ley 教授的在线报告:将ReactIR流动池应用于连续工艺过程技术 或者我最近制作的一个短视频:什么是流动化学?

2010 Fall Meeting Highlights

Now that the busy fall meeting season has come to an end, I wanted to take the opportunity to quickly revisit some highlights that my colleagues and I noted: Continue reading

1st Annual RSC/SCI Continuous Flow Symposium

Jon Goode, Nigel Gaunt, and I attended the 1st Annual Royal Society of Chemistry (RSC)/Society of Chemical Industry (SCI) Continuous Flow Symposium held last week at GlaxoSmithKline in Stevenage, United Kingdom.  Considering that this was the first time this particular event was held, it was very well attended.  This was yet another reminder of what seems to be an ever increasing interest in continuous flow. Continue reading

Optimization and Scale-up of High Shear Wet Granulation Processes

GlaxoSmithKline-GSK-granulation-measurement-FBRM-C35

FBRM® C35 with mechanical wiper for in situ granulation measurement

One goal of high shear granulation is to yield repeatable endpoint granule size, shape, and density distributions. This is necessary for consistent downstream flow properties, tablet consistency, and content uniformity. Quality by Design (QbD) is a concept applied to gain true process understanding through tools such as Design of Experiment (DoE), risk management, and Process Analytical Technology (PAT).

This extended abstract summarizes collaborative research between GlaxoSmithKline (GSK) and METTLER TOLEDO in the application of process analytical technologies (PAT) to the monitoring, optimization and control of High Shear Wet Granulation.

Download the extended abstract for this upcoming conference presentation.

Authors:
Zane Arp, GSK
Eric Dycus, Ben Smith, METTLER TOLEDO
Continue reading