Tag Archives: Grignard reaction

How To Optimize A Highly Reactive Chemistry

Highly Reactive Chemistry

Highly Reactive Chemistry

Highly reactive chemistries are used in the syntheses of drug molecules, special polymer products, herbicides and other agriculture products, high energy materials, and even special materials like nano-particles and chemo-sensors.

Examples of highly reactive chemistries include:

  • Azide chemistry
  • Diazo chemistry
  • Grignard chemistry
  • Lithium chemistry
  • Phosgene chemistry

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Safe Scale-up of a Grignard Reaction – LinkedIn OPRD Group

Recently, I saw a conversation on the LinkedIn Organic Process Research & Development (OPRD) Group that began with the subject:  “Precaution during scale-up of a Grignard reaction?”.  This discussion regarding the safety of Grignard reactions on scale made me realize how useful old chemical reactions can be, although not necessarily well-understood or controlled. Continue reading

Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool – On-Demand Webinar

The on-demand version of the Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool webinar that I presented on January 20 is now available.

View the Reducing Time to Manufacturing On-Demand Webinar.

FTIR-Analytics-Process-Analytical-Technology-Will-Kowalchyk

During this on-demand webinar, I review case studies from the pharmaceutical industry to show how real-time mid-infrared (mid-IR) analytics provide critical information that results in shorter process development timelines, including:

  • Intermediate detection during an indazole alkylation and scale-up – Pfizer
  • Hazardous gas detection during tetrazole synthesis – Merck
  • Monitoring a Grignard reaction at the multikilogram scale – Bristol-Myers Squibb
  • Scale-up involving a sensitive enolate – Johnson and Johnson (J&J)

If you have any questions or would like to discuss this further, then please contact me.