Tag Archives: Focused Beam Reflectance Measurement

Root Cause Analysis For USP Dissolution and Tablet Disintegration Studies

USP dissolution testing is a standard method in pharmaceutical industry to characterize dissolution performance of solid dosage forms. Continue reading

Particle Size Distribution, Particle Shape, and Particle Count – Track Changes

Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO.  It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!

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High Resolution, Fast Understanding, Intuitive Particle Measurement

Inline particle size measurement technology is used to quickly:

  • Understand the particle system’s response when changing process parameters
  • Optimize the particle system to improve process performance and product quality
  • Control the particle system to achieve consistent particle size distribution endpoints, batch repeatability, and process stability Continue reading

PAT & Particle Size Analysis at IFPAC 2011

Three speakers from the 2010 In-Process Particle Forum will present at IFPAC [International Forum Process Analytical Technology] on January 21, 2011 in Baltimore, MD.  Steve Mehrman  of Johnson & Johnson and James Butz of Merck & Co. are scheduled to present during the Particle Characterization/Analysis-Ultrasound Spectroscopy Friday AM V session at IFPAC.  Kevin Macias of Bristol-Myers Squibb will present during the Control Strategies for Drug Product Development and Manufacturing Friday AM VII session. Continue reading

Process Analytical Technology (PAT) in Fermentation

In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration

Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading

How To Track Particle Distribution in Real Time: AAPS 2010

The 2010 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting will be held November 14 to 18 in New Orleans.  As thousands of pharmaceutical scientists from around the world prepare to gather for the AAPS conference that is being held in conjunction with the International Pharmaceutical Federation’s (FIP) Pharmaceutical Sciences World Congress (PSWC), I wanted to highlight some papers that will discuss how to track particle distribution in real-time:

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Predicting Dissolution Quality With Fluid Bed Granulation

Last month, Steve Mehrman of Johnson & Johnson gave a presentation on using Fluid Bed Granulation as a predictor of dissolution performanceContinue reading