More and more scientists routinely use reaction calorimetry thanks to the wider availability and affordability of advanced process calorimetry instruments, their larger volume range (from ml to multi-liter), and ease of use of intuitive software (iControl ). Continue reading
I’m really looking forward to the Continuous Flow Chemistry and Crystallization Development Symposium that will take place in New Brunswick, NJ on September 26. Two colleagues will present new crystallization research that I think will be of interest to the local scientific community. Continue reading
In pharmaceutical development, the drive for better drug product quality, process reliability, efficiency and safety have become key factors in driving chemists and engineers to seek alternative methodologies. Continuous flow reactor technologies significantly expand the range and scope of possible chemistries, and allow for rapid testing, optimization, and scaling of chemical sequences. This is reflected in the dramatic increase in the variety and depth of published chemistry over the last few years. Continue reading
A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode. Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated. Continue reading
The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.
The 3rd Symposium on Continuous Flow Reactor Technology for Industry Applications will be held October 3 and 4 in Como, Italy. This Symposium focuses on: Continue reading