The Analysis of Particle Sizes in Process: Measuring Techniques for Emulsions and Suspensions Workshop takes place this week (October 10-12) at the University of Potsdam Institute for Chemistry. This workshop not only focuses the theory of particle size but also the technology that can be used for real-time, in-process measurements. One of the most interesting sessions will be on the emerging areas where particle size is gaining traction – particle measurement in biotechnology. Continue reading
The 2011 American Institute of Chemical Engineers (AIChE) Annual Meeting took place October 16 to 21 in Minneapolis, MN. The AIChE Annual Meeting is a terrific event to: Continue reading
Since the Seattle area is well known for biotech, I was not surprised when the November Puget Sound American Institute of Chemical Engineers (AIChE) meeting focused on the cell fermentation process at Amgen. The AIChE meeting featured the presentation by Amgen’s Anna Senczuk: Continue reading
In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration
Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading
Process Analytical Technology (PAT) for Biotech: A Review of Recently Reported Applications in Fermentation and BioProcessing
Fermentation and bioprocessing play critical roles in the discovery and manufacture of new pharmaceuticals and specialty chemicals, and in the sustainable production of bulk fuels and commodity chemicals. Yet fermentation processes are often operated with a minimal level of monitoring and control, limiting the ability to optimize yields and production rates. Continue reading
Here are citations from papers that discuss Process Analytical Technology (PAT) in Fermentation as it specifically relates to biomass monitoring using real-time particle system characterization: Continue reading
Brian O’Sullivan will present Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity on May 26. During this free online seminar, case studies where Process Analytical Technology (PAT) was successfully applied to fermentation processes – including filamentous organisms, plant cells, mammalian cells, and E. Coli – will be reviewed.
Specific application examples that Brian will discuss are protein crystallization optimization, scale-up from shaker flasks to pilot scale, cell debris & cell debris flocculation, cell count & cell density monitoring in real time with no need for sampling, and cell culture productivity.
Visit the Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity online seminar page for more information.