Tag Archives: fermentation process

Process Analytical Technology (PAT) in Fermentation

In Situ Monitoring of Biomass, Cell Growth and Cell Agglomeration

Real-time monitoring of the cell population within a bioreactor provides invaluable information regarding biomass concentration and growth kinetics that can be essential for detailed characterization and control of the fermentation process. Additionally, real-time information related to cell morphology, aggregation, and floc size have also been documented and shown to aid in the understanding and optimization of bioprocesses. Continue reading

Using Process Analytical Technology (PAT) to Ensure Targeted Cell Culture Productivity

Cell-Culture-Fermentation-Brian-OSullivan-METTLER-TOLEDO

Tracking Inline Cell Count and Dimension

Brian O’Sullivan will present Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity on May 26.    During this free online seminar, case studies where Process Analytical Technology (PAT) was successfully applied to fermentation processes – including filamentous organisms, plant cells, mammalian cells, and E. Coli – will be reviewed.

Specific application examples that Brian will discuss are protein crystallization optimization, scale-up from shaker flasks to pilot scale, cell debris & cell debris flocculation, cell count & cell density monitoring in real time with no need for sampling, and cell culture productivity.

Visit the Tracking Inline Cell Count and Dimension to Ensure Targeted Cell Culture Productivity online seminar page for more information.