Tag Archives: FBRM

Focused Beam Reflectance Measurement

Impact of Process Parameters on Supersaturation and Crystal Size and Shape

This is the fifth blog post in a series dedicated to crystallization.  In case you missed the previous posts in the series, they are available here:

The diagram below illustrates the relationship between supersaturation and crystal size distribution, via crystal nucleation and growth. In this post, we will look at how supersaturation can be controlled by adjusting process parameters such as antisolvent addition rate. Continue reading

高度的分辨率、快速的理解、直观的颗粒测量

在线颗粒大小测量技术被用于快速地:

  • 理解颗粒系统随工艺过程参数变化而发生的相应变化
  • 优化颗粒系统从而改进工艺性能及产品质量
  • 控制颗粒系统从而获得颗粒大小分布终点的一致性、批次的重复性、和工艺的稳定性

颗粒大小分析只有当原位颗粒测量方法具有代表性并容易理解时,人们才可能实现相应的工艺过程优化与控制。基于20年在线颗粒测量的经验,新一代的聚光反射测量(FBRM) 被重新设计后针对每一个实验具备更高的玄长测量分辨率,并且提供更加直观的信息。

科学家和工程师们用FBRM来跟踪工艺过程中自然存在状态下的颗粒与液滴。 新一代的FBRM技术 – FBRM G400 和 FBRM G600 – 增强了分辨率,同时提供对颗粒系统的直观理解。这使其使用者们可以在更短的时间内提高实验通量并改进产品质量。

请观看新的在线颗粒特征分析的突破性性能报告。

该报告的重点包括:

先进的信号处理

  • 更高的玄长分布分辨率为每一个实验提供更多的信息量
  • 粘贴颗粒的矫正改进信息的可靠性以及对工艺的理解

FBRM G400 先进的硬件开发

  • 可互换的探头平台改进多用适应性和可携带性
  • 改进的探头牢靠程度降低维修频率

Inline Particle Size, Shape & Count History: Lasentec® FBRM®

particle size Lasentec FBRM

For over 25 years, FBRM® technology has been used for real-time monitoring of particles and droplets as they naturally exist in process.   Continue reading

Particle Size Distribution, Particle Shape, and Particle Count – Track Changes

Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO.  It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!

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NESACS’s Bench to Plant Symposium

NESACS SymposiumUpon returning to the Boston area after a number of years away, I was very much looking forward to attending The Northeastern Section of the American Chemical Society (NESACS)’s Advances in Chemical Sciences “Bench to Plant” Symposium for the first time.  Held in Cambridge on October 22, about 100 scientists from the local area gathered for the one day Symposium focusing on Process R&D Chemistry, Organic Synthesis, and New Synthetic Methodology.

Some highlights of the top-notch presentations included:

Continue reading

PSAIChE 生物技术:用实时颗粒特性分析优化絮凝过程

西雅图〔美国华盛顿州港市〕地区的生物技术众所周知,所以我并不惊奇在十一月举行的Puget Sound 美国化学工程师学会 (AIChE) 会议将重点放到了Amgen的细胞发酵工艺过程上。Amgen的Anna Senczuk在此次AIChE会议上作了这一报告:颗粒分布和胆固醇高低作为细胞培养菌絮凝和过滤性能的预报因子

随着近年来细胞发酵技术的提高,大部分细胞发酵过程每釜所含细胞密度较高。细胞越多蛋白质含量越高,产物产率便增加。对具有大量细胞要警戒的是去除细胞的工艺过程。事实证明传统的细胞去除方法效率不佳。

Anna Senczuk的研究工作一部分是确定如何应用絮凝方法来除去来自细胞培养菌的固体。絮凝技术已在各种工业领域使用多年,包括水清洁、纸浆/矿浆、和造纸业。作为细胞去除项目的一部分,Anna研究并开发出了一个新型的、改进了的、使用絮凝和传统细胞去除技术的工艺过程。

在此项目中, Anna的研究目的包括:

  • 理解絮凝在其工艺过程中如何起作用
  • 颗粒分布分析能否帮助优化絮凝?
  • 颗粒分布与过滤特性之间是否直接相关?

Anna用在她研究中的各种方法包括FBRM (聚光反射测量), SHC过滤作为一种分析手段,和脂类分析(过滤器的筛选和吸附特性)。FBRM是一个原位颗粒特性分析技术,测量工艺过程中真实存在的细胞絮凝粒/碎片。实时测量所得信息然后与其它技术的结果(像过滤速率 )相关联,从而对工艺过程获得理解并予以优化。

(此前我也曾讨论过絮凝过程,请看我的博贴:Why Is Canada Reducing Oil Sand Tailing Ponds?

High Resolution, Fast Understanding, Intuitive Particle Measurement

Inline particle size measurement technology is used to quickly:

  • Understand the particle system’s response when changing process parameters
  • Optimize the particle system to improve process performance and product quality
  • Control the particle system to achieve consistent particle size distribution endpoints, batch repeatability, and process stability Continue reading

Enhance Your Understanding of a Crystallization Process

A common challenge faced by both chemists and engineers is how to achieve an enhanced understanding of the crystallization process.

The EasyMax has provided a powerful, yet nimble platform for chemists and engineers to get a lot of work done.  It has been great to see how well the EasyMax has been embraced, especially for crystallization work.  Simon Rea developed a way to make it even better for particle characterization:

Crystallization Process FBRM PVM EasyMax

At last, you can use the FBRM and PVM simultaneously in your EasyMax!  This new PTFE lid makes it possible to see your: Continue reading

IFPAC 2011上谈PAT与颗粒大小分析

2010工艺过程中的颗粒论坛会上的三位报告者将在2011年1月21日于(美国)马里兰州的巴尔的摩举行的IFPAC (工艺过程分析技术国际论坛)上作报告。Johnson & Johnson的Steve Mehrman和Merck & Co. 的James Butz被排在周五上午的“颗粒特征分析超声光谱”IFPAC 的第五分会作报告。Bristol-Myers Squibb的Kevin Macias将在周五上午的“药品开发与生产的控制战略”第七分会中作报告。 Continue reading

PAT & Particle Size Analysis at IFPAC 2011

Three speakers from the 2010 In-Process Particle Forum will present at IFPAC [International Forum Process Analytical Technology] on January 21, 2011 in Baltimore, MD.  Steve Mehrman  of Johnson & Johnson and James Butz of Merck & Co. are scheduled to present during the Particle Characterization/Analysis-Ultrasound Spectroscopy Friday AM V session at IFPAC.  Kevin Macias of Bristol-Myers Squibb will present during the Control Strategies for Drug Product Development and Manufacturing Friday AM VII session. Continue reading