Tag Archives: EasyMax

The Future of Chemical Research and Development: The Demise of the Round Bottomed Flask

ISPE-New-England-Chapter-BioPharma-ConferenceLast Thursday, May 6th, I attended the ISPE (International Society for Pharmaceutical Engineering) New England Chapter Biopharma 2010 Conference held in Warwick, Rhode Island.  A presentation was given by Geraldine Taber, Pfizer’s Global Technology Group Leader titled “Demise of the Round-Bottomed Flask – How new Battle Tools in the Lab of the Future are delivering value for R&D”.

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Chemical & Engineering News: Highlighting Recent Letters Discussing Chemical Process Safety

A few months ago, I came across two letters in Chemical & Engineering News that I would like to bring to your attention. Both letters relate to ensuring the safety of chemical processes.

The first, from Tom Vickery and colleagues at Merck, made the point that a recently published procedure (for preparation of 2-bromo-3-methylbutenal) presents a safety issue with dramatic consequences for scale-up:

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A Conversation with Danny Levin at Scientific Update’s January 2010 Organic Process R&D Meeting in San Diego


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Figure 1 - Summary of OPRD article by Danny Levin et al

I recently had a chance to meet with Danny Levin, President at Norac Pharma, during the 21st International Conference on Organic Process Research & Development (Scientific Update), January 2010, San Diego, CA.

After my presentation at the Organic Process Research & Development (OPRD) conference, Danny Levin described a paper he published a few years ago when he was head of research at NPIL Pharma Torcan (Org. Process Res. Dev., 2006, 10(6), pp 1296–1298). I had already used Danny Levin’s paper several times in my conference talks (figure 1) to illustrate the power of heat flow (Tr-Tj) at small scale, and Danny graciously provided some additional insight:

“I thought you might be interested in a publication of my own where I used METTLER TOLEDO MultiMax to good purpose in identifying and mitigating process scale up safety concerns during process development of a Horner Wadsworth Emmons reaction […]

The situation with the case study that I published was that we had been given a chemistry procedure that was believed by the originator to be safe and under control by virtue of slow addition of reagents. The MultiMax plot of (Tr-Tj) showed that this wasn’t the case – reagents were accumulating and the reaction and all the significant heat output occurred during warming for work-up!!!

It was the MultiMax data that quickly demonstrated the scale up hazard and allowed us to define a safely scaleable process. This critical aspect was not obvious from the presentation summary you kindly sent. You may wish to emphasize this point in future presentations to demonstrate the role of MultiMax in identifying and highlighting unsafe chemistry”.

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Free Chemistry and Chemical Engineering Webinars – February 2010

METTLER TOLEDO is pleased to provide the following free webinars next month (February 2010).

Wednesday, February 3, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant – Part II

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Guest Presenter:

Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland

Register for Part II of Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant

Wednesday, February 10, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization of Crystallization Processes

Guest Presenter:

Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland

Register for the Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes

Thursday, February 18, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Conversion Prediction of an Enzymatic Esterification with the ReactIR 45m and iC Quant

Guest Presenters:

Prof Dr. Andreas Liese and Jakob Muller – Hamburg University of Technology (TUHH) – Germany

Register for the Conversion Prediction of an Enzymatic Esterification with the ReactIR 45m and iC Quant

Our free chemistry and chemical engineering webinars are presented by experts on topics of interest in chemical and pharmaceutical development and manufacturing, including: organic synthesis and reaction monitoring, crystallization, process development, scale-up of chemical processes and process safety.

If you cannot attend any live session, your registration will provide on-demand access to the webinar after the date scheduled.

Visit our website to register for any of our upcoming or on-demand webinars
(over 80 Chemistry and Chemical Engineering topics available On-Demand).