Seeding has become one of the most critical steps in optimizing crystallization behavior, process efficiency, and product quality. Inconsistent filtration rates, drying times, yields, bulk density, flow properties, and particle size distributions can often be traced back to inconsistent seeding and nucleation. Many parameters must be taken into consideration when designing a seeding strategy such as seed size, seed loading (mass) and seed addition temperature. These parameters are generally optimized based on process kinetics and the desired final particle properties and must remain consistent during scale-up and technology transfer. Continue reading
Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to produce a fine crystal distribution in situ, downstream milling operations are avoided, thus improving the yield, and reducing energy consumption or safety hazards which may arise due to milling. Continue reading
Transferring a crystallization to manufacturing or a contract partner is a critical step.
httpv://www.youtube.com/watch?v=S5QlM9BZZr8 Continue reading
Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Continue reading
Crystallization and precipitation are critical processing steps in chemical development. They can serve as purification and separation steps, and have implications on the yield, purity and particle size distribution. Even though crystallization has advanced significantly over the past decade, many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ. Due to the complexity of crystallization, a process may be developed simply by crashing solids out of solution and transferring a non-robust process with inconsistencies in the yield, purity and particle size distribution. Continue reading
Recently, I met several scientists who did not realize Lasentec® (Lasentech) was acquired by METTLER TOLEDO. It is hard to believe that it has already been 10 years since METTLER TOLEDO acquired Lasentec® and became the world leader for inline particle characterization technology!
This is the fourth blog post in a series dedicated to crystallization. In case you missed the previous blog posts in the series, they are available here: Introduction to Crystallization and Precipitation, Common Ways to Reduce Solubility and Drive Crystallization, Supersaturation: Driving Force for Crystal Nucleation & Growth.
The set of PVM images below neatly illustrates the complex size, shape and structure of crystals. From large round “boulders” to beautifully delicate “dendrites”, crystal product is often varied, posing challenges to effective separation and downstream manipulation. Continue reading