Tag Archives: Crystallization

19th Larson Workshop – ACT (Association for Crystallization Technology)

I am very much looking forward to attending the 19th Larson Workshop – ACT (Association for Crystallization Technology) conference in Indianapolis  next week (October 6-9).

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Chicago Chemical and Crystallization R&D Event

My colleagues and are hosting a free Chemical and Crystallization R&D Event at the Westin O’Hare Hotel on Thursday, May 23.  The event is aimed towards scientists and researchers working in chemical and crystallization R&D and scale-up. We have six excellent speakers from industry and academia presenting at this event: Continue reading

Measuring Fines Precipitation to Improve Solid/Liquid Separations

Poor filtration and bulk density are often related to the number of fine particles present in a system. Inline particle size and count measurements identify the exact moment and conditions when fine particle formation occurs. By pinpointing the source of the inconsistency, the root cause can be identified, and a smarter process may be developed with improved solid/ liquid separations. Continue reading

Best Practice For Inline Particle Size Characterization

 Chemists, engineers, and biologists are often challenged by processes involving particle or droplet systems. Solid or liquid dispersion, homogenization, agglomeration, or precipitation can create variability in product stability and manufacturing throughput. To develop and manufacture world class products at competitive costs, scientists and engineers use inline particle size measurements to optimize process conditions and consistently meet product quality specifications, at the bench or in manufacturing. Continue reading

Advances For Seeding A Crystallization Process

Seeding has become one of the most critical steps in optimizing crystallization behavior, process efficiency, and product quality. Inconsistent filtration rates, drying times, yields, bulk density, flow properties, and particle size distributions can often be traced back to inconsistent seeding and nucleation. Many parameters must be taken into consideration when designing a seeding strategy such as seed size, seed loading (mass) and seed addition temperature. These parameters are generally optimized based on process kinetics and the desired final particle properties and must remain consistent during scale-up and technology transfer. Continue reading

Crystallization Research Information Sharing

I’m really looking forward to the Continuous Flow Chemistry and Crystallization Development Symposium that will take place in New Brunswick, NJ on September 26.  Two colleagues will present new crystallization research that I think will be of interest to the local scientific community.  Continue reading

Continuous Flow Chemistry & Crystallization Development Symposium

In pharmaceutical development, the drive for better drug product quality, process reliability, efficiency and safety have become key factors in driving chemists and engineers to seek alternative methodologies. Continuous flow reactor technologies significantly expand the range and scope of possible chemistries, and allow for rapid testing, optimization, and scaling of chemical sequences. This is reflected in the dramatic increase in the variety and depth of published chemistry over the last few years. Continue reading

HANBAT International Workshop on Industrial and Pharmaceutical Crystallization

Crystallization is a complicated process where the final crystal product is a function of thermodynamics as well as kinetic and physical phenomenon. Continue reading

19th International Workshop on Industrial Crystallization – BIWIC 2012

During BIWIC 2012 (19th International Workshop on Industrial Crystallization) in China, I will present a poster – Amalgamated Sugar Experiences with Inline Particle Size, Shape, and Count Characterization:  Real-Time Crystal Nucleation and Growth Rates in an Industrial Semi-batch Crystallizer. Continue reading

Upcoming Crystallization Conferences and Events

There are several interesting upcoming crystallization conferences and meetings. Continue reading