Tag Archives: crystallization supersaturation

Automating Crystallization Development

On Wednesday, I presented an online seminar: Automating Crystallization Development: Metastable Zone Width Determination and Supersaturation Control, which summarized a two day collaboration with a major pharmaceutical company where crystallization development time was reduced and scale-up efficiency was improved. Continue reading

Supersaturation Or the Crystal Size Distribution

Supersaturation or the Crystal Size DistributionWhich Measurement Is More Important?

In an ideal world, you may want to directly measure the crystal population within the crystallizer (a critical product quality attribute) and measure the supersaturation which is driving the process (a critical process parameter).  Today’s advanced Process Analytical Technology (PAT) allows you to measure both of these critical parameters in real time. But where should you begin – especially if budget constraints limit you to implementing only one advanced measurement. Continue reading

What Makes Crystallization Such a Complex Process?

As a follow-up on last week’s post regarding the implications of a well-designed crystallization process, including how Tim Bell of DuPont Engineering wrote: “Crystallization is notoriously difficult to scale-up…”, we will now address why crystallization is such a complex process. Continue reading