Tag Archives: crystallization process

Robust Crystallization Processes Developed With Workstations

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Designing Effective and Efficient Crystallization Processes

This is the sixth blog post in a special series dedicated to crystallization.  In case you missed the previous posts in the series, they are available here:

Previously, we looked at a case study that neatly illustrated the concept that slow supersaturation generation often results in a growth dominated process that is typically repeatable. As a rule of thumb, slow cooling works great – but its main drawback is the extended cycle times that often result. To overcome this problem, a common technique often used is non-linear cooling.

If we dive a little bit deeper into the governing equations of crystal growth and nucleation.. Continue reading

Introduction to Crystallization & Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture. Salt and sugar are delivered to our dinner tables as crystals. The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

Crystallization in the Pharmaceutical Industry – Shanghai Training

A technical training on Crystallization Technologies in the Pharmaceutical Industry will be held on June 23-24 in Shanghai, China.  Continue reading

Enhance Your Understanding of a Crystallization Process

A common challenge faced by both chemists and engineers is how to achieve an enhanced understanding of the crystallization process.

The EasyMax has provided a powerful, yet nimble platform for chemists and engineers to get a lot of work done.  It has been great to see how well the EasyMax has been embraced, especially for crystallization work.  Simon Rea developed a way to make it even better for particle characterization:

Crystallization Process FBRM PVM EasyMax

At last, you can use the FBRM and PVM simultaneously in your EasyMax!  This new PTFE lid makes it possible to see your: Continue reading

Introduction to Crystallization and Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture.  Salt and sugar are delivered to our dinner tables as crystals.  The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

What Makes Crystallization Such a Complex Process?

As a follow-up on last week’s post regarding the implications of a well-designed crystallization process, including how Tim Bell of DuPont Engineering wrote: “Crystallization is notoriously difficult to scale-up…”, we will now address why crystallization is such a complex process. Continue reading

Implications of a Well-Designed Crystallization Process

well-designed crystallization processCrystallization is a critical process for the purification and isolation of chemical compounds in the manufacture of many fine chemical and pharmaceutical products. The results of the crystallization step have far reaching impacts on overall process efficiency and final product quality. Crystallization is also a very difficult process to effectively optimize and control. Crystallization is inherently complicated simply by being a process involving the creation and formation of solid particles.

Timothy A. Bell, of DuPont Engineering Research and Technology, wrote a review of the challenges of scaling-up particulate processes where he stated: Continue reading

Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes On-Demand Webinar

In case you missed the live webinar, Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes, presented today by Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland, the on-demand version of  Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes is now available.

View the Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes on-demand webinar.

If you are interested in discussing Crystallization topics with Mark Barrett and over 300 others who work in Crystallization, I invite you to join the LinkedIn Crystallization Community.

Track Real-Time Changes to Crystal Size, Shape, & Count

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