Tag Archives: crystal

HANBAT International Workshop on Industrial and Pharmaceutical Crystallization

Crystallization is a complicated process where the final crystal product is a function of thermodynamics as well as kinetic and physical phenomenon. Continue reading

Engineering Fine Particle Size Distributions with Inline Particle Size Measurements

Crystal engineering is applied when the crystal size distribution is too large to meet downstream specifications. By designing the crystallization to produce a fine crystal distribution in situ, downstream milling operations are avoided, thus improving the yield, and reducing energy consumption or safety hazards which may arise due to milling. Continue reading

Upcoming Crystallization Conferences and Events

There are several interesting upcoming crystallization conferences and meetings. Continue reading

How To Optimize Crystal Size Distribution, Improve Filtration Rates, and Batch Consistency

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Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Continue reading

How To Develop More Robust Crystallization Processes

Crystallization and precipitation are critical processing steps in chemical development. They can serve as purification and separation steps, and have implications on the yield, purity and particle size distribution. Even though crystallization has advanced significantly over the past decade, many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ. Due to the complexity of crystallization, a process may be developed simply by crashing solids out of solution and transferring a non-robust process with inconsistencies in the yield, purity and particle size distribution. Continue reading

Introduction to Crystallization & Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture. Salt and sugar are delivered to our dinner tables as crystals. The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

Impact of Process Parameters on Supersaturation and Crystal Size and Shape

This is the fifth blog post in a series dedicated to crystallization.  In case you missed the previous posts in the series, they are available here:

The diagram below illustrates the relationship between supersaturation and crystal size distribution, via crystal nucleation and growth. In this post, we will look at how supersaturation can be controlled by adjusting process parameters such as antisolvent addition rate. Continue reading

Supersaturation: Driving Force For Crystal Nucleation & Growth

This is the third blog post in a series dedicated to crystallization.  In case you missed the first and second in the series, they are available here: Introduction to Crystallization and Precipitation and Common Ways to Reduce Solubility and Drive Crystallization.

Supersaturation is the driving force for all solution crystallization processes. Crystallization scientists gain control over crystallization process and product quality by carefully controlling the prevailing level of supersaturation during the process. Continue reading