Tag Archives: crystal size distribution

How To Optimize Crystal Size Distribution, Improve Filtration Rates, and Batch Consistency

httpv://www.youtube.com/watch?v=5VeCg6LQSYY

Chemists and Engineers need to quickly develop repeatable crystallization processes with fast cycle times. Continue reading

Impact of Process Parameters on Supersaturation and Crystal Size and Shape

This is the fifth blog post in a series dedicated to crystallization.  In case you missed the previous posts in the series, they are available here:

The diagram below illustrates the relationship between supersaturation and crystal size distribution, via crystal nucleation and growth. In this post, we will look at how supersaturation can be controlled by adjusting process parameters such as antisolvent addition rate. Continue reading

Supersaturation: Driving Force For Crystal Nucleation & Growth

This is the third blog post in a series dedicated to crystallization.  In case you missed the first and second in the series, they are available here: Introduction to Crystallization and Precipitation and Common Ways to Reduce Solubility and Drive Crystallization.

Supersaturation is the driving force for all solution crystallization processes. Crystallization scientists gain control over crystallization process and product quality by carefully controlling the prevailing level of supersaturation during the process. Continue reading

Supersaturation Or the Crystal Size Distribution

Supersaturation or the Crystal Size DistributionWhich Measurement Is More Important?

In an ideal world, you may want to directly measure the crystal population within the crystallizer (a critical product quality attribute) and measure the supersaturation which is driving the process (a critical process parameter).  Today’s advanced Process Analytical Technology (PAT) allows you to measure both of these critical parameters in real time. But where should you begin – especially if budget constraints limit you to implementing only one advanced measurement. Continue reading

What Makes Crystallization Such a Complex Process?

As a follow-up on last week’s post regarding the implications of a well-designed crystallization process, including how Tim Bell of DuPont Engineering wrote: “Crystallization is notoriously difficult to scale-up…”, we will now address why crystallization is such a complex process. Continue reading