Tag Archives: cooling

Polymorph Form Control: Why Care About Seeding and Cooling Rates?

In Situ Monitoring of Supersaturation and Polymorphic Form of Piracetam during Batch Cooling Crystallization

Mark Barrett and others at the University College Dublin (UCD) recently published a paper Continue reading

Common Ways to Reduce Solubility and Drive Crystallization

This is the second blog post in a series dedicated to crystallization. In case you missed the first in the series, you can find it here: Introduction to Crystallization and Precipitation.

Reduce Solubility and Drive CrystallizationThe starting point for most crystallization processes is a saturated solution. Crystallization is generally achieved by reducing the solubility of the product in this solution by cooling, antisolvent addition, evaporation* or some combination of these methods. Another common method used to drive crystallization is via a chemical reaction where two or more reactants are mixed to form a solid product insoluble in the reaction mixture; a common example of this would be the reaction of an acid and a base to form a salt. Continue reading

Common Ways to Reduce Solubility and Drive Crystallization

This is the second blog post in a series dedicated to crystallization.  In case you missed the first in the series, you can find it here: Introduction to Crystallization and Precipitation.

Reduce Solubility and Drive CrystallizationThe starting point for most crystallization processes is a saturated solution. Crystallization is generally achieved by reducing the solubility of the product in this solution by cooling, antisolvent addition, evaporation* or some combination of these methods. Another common method used to drive crystallization is via a chemical reaction where two or more reactants are mixed to form a solid product insoluble in the reaction mixture; a common example of this would be the reaction of an acid and a base to form a salt. Continue reading