The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.
Regular visitors to this blog will be familiar with recent continuous flow chemistry events in what I consider to be a very exciting, fast-developing area of chemistry. When I was reading the recent blog post regarding the upcoming Pfizer Flow Technology Expo, I thought about other upcoming flow chemistry events, including: Continue reading →
Continuous flow chemistry is widely used in the chemical and petrochemical markets, and has been for decades. The continuous flow chemistry production methodology has been gaining interest in pharmaceutical R&D due to: Continue reading →
Modern flow reactors can deliver a number of distinct advantages over more traditional batch reactor technology. For example, reaction conditions that may be challenging to achieve in a batch reactor can be easier to achieve in a flow reactor. A good example is a reaction in which the temperature of the reaction far exceeds the boiling point of the solvent. This type of reaction can be easily run due to the flow reactor’s ability to contain pressure. (The ThalesNano’s H-Cube pictured above is a widely used CFR designed specifically to simplify screening and development of continuous hydrogenation reactions.) Continue reading →