Tag Archives: chemistry

AIChE Annual Meeting 2012

I’m really looking forward to attending the annual American Institute of Chemical Engineers (AIChE) meeting in Pittsburgh, PA this year. It is always a great opportunity to meet excellent scientists working in very diverse areas. As a chemical engineer it is also nice to focus on chemical engineering for a change! – since many of the conferences I attend are chemistry orientated.

It is also great to see so many papers being presented that Continue reading

Crystallization Research Information Sharing

I’m really looking forward to the Continuous Flow Chemistry and Crystallization Development Symposium that will take place in New Brunswick, NJ on September 26.  Two colleagues will present new crystallization research that I think will be of interest to the local scientific community.  Continue reading

Continuous Flow Chemistry & Crystallization Development Symposium

In pharmaceutical development, the drive for better drug product quality, process reliability, efficiency and safety have become key factors in driving chemists and engineers to seek alternative methodologies. Continuous flow reactor technologies significantly expand the range and scope of possible chemistries, and allow for rapid testing, optimization, and scaling of chemical sequences. This is reflected in the dramatic increase in the variety and depth of published chemistry over the last few years. Continue reading

Use a Continuous Flow Reactor to Monitor Product Streams & Dispersion Effects

A flow chemistry system in combination with solid-supported reagents and scavengers was used to perform fluorination reactions in a continuous mode.   Using an inline analysis method, the effect of the solid supported reagents and scavengers on the product stream can be investigated.  Continue reading

Flow Chemistry – What’s Happening?

The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.

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Optimization of Highly Reactive Chemistry – Reducing Risks

Highly reactive chemistry is the generic term referring to chemical reactions that pose a challenge due to the potentially hazardous and/or energetic nature of the reactants, intermediates and products that are present during synthesis. Highly reactive chemistries include Grignard, acid chloride, azide, halogenation, and hydrogenation.  Continue reading

Synthetic Chemistry Beyond The Round Bottom Flask

While analytical technologies that support synthetic organic chemistry in the laboratory have changed dramatically, chemical synthesis itself has remained largely unchanged for over fifty years.  During that time, the round bottom flask has been the workhorse for organic chemists in the synthesis lab. Continue reading