Tag Archives: chemical development

Flow Chemistry – What’s Happening?

The desire to gain major improvements in product quality, yield, synthetic route, cycle time and safety in chemical processes have become key driving factors for chemists and engineers working in the chemical development and manufacturing environment in the pharmaceutical and fine chemical industries. In order to achieve these goals, scientists are actively seeking alternative chemical development methods such as modern continuous flow reactor technologies. These technologies provide the opportunity to address many of these issues as they allow for rapid testing, optimization, and scaling of chemical sequences, many of which are unsafe for batch operations.

Continue reading

Improve Organic Synthesis in 4 Ways

After writing last week regarding recent advances to improve chemical development in the pharmaceutical industry, there were a lot of discussions about the top 4 ways to improve organic synthesis. Continue reading

4 Ways To Improve Organic Synthesis

In collaboration with Pfizer, I will make a presentation on Four Ways To Improve Organic Synthesis on July 20, 2011. Continue reading

Process Development Conference, Weggis, Switzerland

I am happy to announce that the 18th International Process Development Conference (IPDC) will be held September 25 to September 29, 2011 in Weggis, Switzerland.  This year’s conference will focus on workflows from compound development to manufacturing in the pharmaceutical, fine and specialty chemical industries: Continue reading

1st Annual RSC/SCI Continuous Flow Symposium

Jon Goode, Nigel Gaunt, and I attended the 1st Annual Royal Society of Chemistry (RSC)/Society of Chemical Industry (SCI) Continuous Flow Symposium held last week at GlaxoSmithKline in Stevenage, United Kingdom.  Considering that this was the first time this particular event was held, it was very well attended.  This was yet another reminder of what seems to be an ever increasing interest in continuous flow. Continue reading

How Pfizer Is Improving Process Development For Bench Scientists

Recently, Dr. Marty Guinn, Director of Chemical Development for Pharma Therapeutics at Pfizer, wrote: Continue reading

How Johnson and Johnson Replaced The Round Bottom Flask

Janssen Pharmaceutica Belgium is part of Johnson & Johnson, the world’s largest health care company. Thanks to Johnson and Johnson’s extensive engagement in innovative science, and investment in highly educated people and advanced research equipment, Janssen Pharmaceutica enjoys an international reputation for pharmaceutical innovation and quality. Continue reading

Early Phase Implementation of Process Analytical Technology (PAT) Tools in Chemical Development

In the pharmaceutical industry, the pressure to decrease development times for new chemical entities is common.  During the recent 17th International Process Development Conference, Terry Connelly of Pfizer discussed this particular challenge during the presentation “Examples of Early Phase Implementation of Process Analytical Technology (PAT) Tools:  Meeting Short Term Goals While Setting the Stage for Long-Term Process Understanding and Control”.
Continue reading