Tag Archives: biocatalysis

How To Monitor Biocatalysis in Real Time

This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.

Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading

Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries

Last week, John Tedesco and I had the privilege to attend the 3rd International Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries in Boston, MA. Continue reading

Process Analytical Technology (PAT) for BioCatalysis

Below are citations from interesting papers that discuss Process Analytical Technology (PAT) for BioCatalysis, highlighting faster development and optimization of scalable processes: Continue reading

Use of Real-Time In Situ Reaction Analysis in Research

Real-time in situ reaction analysis is used by the world’s top researchers to increase the understanding of organic chemistry in the following research areas:

Continue reading

Free Chemistry and Chemical Engineering Webinars – February 2010

METTLER TOLEDO is pleased to provide the following free webinars next month (February 2010).

Wednesday, February 3, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant – Part II

Crystallization-Webinars-Mark-Barrett-METTLER-TOLEDO

 

Guest Presenter:

Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland

Register for Part II of Optimization and Scale-up of a Hydrodynamically Limited Anti-Solvent Crystallization Process: From Lab to Plant

Wednesday, February 10, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization of Crystallization Processes

Guest Presenter:

Mark Barrett, Ph.D., Senior Research and Development Engineer, Solid State Pharmaceutical Cluster (SSPC) – Ireland

Register for the Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes

Thursday, February 18, 2010 – (4:00 AM, 9:00 AM, 2:00 PM EST)
Conversion Prediction of an Enzymatic Esterification with the ReactIR 45m and iC Quant

Guest Presenters:

Prof Dr. Andreas Liese and Jakob Muller – Hamburg University of Technology (TUHH) – Germany

Register for the Conversion Prediction of an Enzymatic Esterification with the ReactIR 45m and iC Quant

Our free chemistry and chemical engineering webinars are presented by experts on topics of interest in chemical and pharmaceutical development and manufacturing, including: organic synthesis and reaction monitoring, crystallization, process development, scale-up of chemical processes and process safety.

If you cannot attend any live session, your registration will provide on-demand access to the webinar after the date scheduled.

Visit our website to register for any of our upcoming or on-demand webinars
(over 80 Chemistry and Chemical Engineering topics available On-Demand).