Tag Archives: batch crystallization

Process Analytical Technology at EuroPACT 2011

As I look ahead to 2011, an event of interest is EuroPACT 2011: the second European Conference on Process Analytics and Control Technology.  The EuroPACT 2011 event will be held April 26 to 29 in Glasgow.  Founded in 2006, the EuroPACT conference covers new technologies in process analytics and process performance monitoring, and the implementation of these technologies in various technological fields, including the transformation of data into knowledge, and industrial sectors.

One poster presentation that I wanted to highlight is – Faster Optimization and Troubleshooting with Process Analytical Technology: Real-time Measurement of the Crystal Population. Continue reading

Crystallization control: measuring supersaturation with ReactIR, or measuring crystal nucleation and growth with FBRM

Crystallization-control-FBRM-EasyMax-crystallizer-METTLER-TOLEDO

Crystallization control

A question was posted regarding crystallization monitoring and control:

“If you had to choose between supersaturation control or FBRM crystal size control on an industrial scale, which would you choose?”

Supersaturation monitoring and control only makes sense if you have a very reliable model of the system (i.e. where you can predict nucleation and growth as a function of supersaturation), stable reactor control, and a precise supersaturation measurement.

In R&D this is certainly achievable, and there are good examples of supersaturation control including this on-demand webinar, by Dr. Mark Barrett, describing calibration-free supersaturation control.

However, in an industrial crystallizer, your supersaturation-based control would likely be based on limiting the level of supersaturation to avoid conditions that would produce high levels of spontaneous or secondary nucleation.

And that’s not really control, just avoidance.

Continue reading