Tag Archives: AIChE

AIChE 2013 Spring Meeting and 9th Global Congress on Process Safety

I would like to thank the American Institute of Chemical Engineers (AIChE) and William Hollar (Sabic) for inviting METTLER TOLEDO to present a paper at AIChE Spring 2013 Session in San Antonio last week. The session –  New Approaches in Chemical Manufacturing Operations – Continue reading

AIChE Annual Meeting 2012

I’m really looking forward to attending the annual American Institute of Chemical Engineers (AIChE) meeting in Pittsburgh, PA this year. It is always a great opportunity to meet excellent scientists working in very diverse areas. As a chemical engineer it is also nice to focus on chemical engineering for a change! – since many of the conferences I attend are chemistry orientated.

It is also great to see so many papers being presented that Continue reading

2011 AIChE Annual Meeting Highlights

The 2011 American Institute of Chemical Engineers (AIChE) Annual Meeting took place October 16 to 21 in Minneapolis, MN.  The AIChE Annual Meeting is a terrific event to: Continue reading

What is Happening in Crystallization

Here is what is happening in crystallization: Continue reading

PSAIChE 生物技术:用实时颗粒特性分析优化絮凝过程

西雅图〔美国华盛顿州港市〕地区的生物技术众所周知,所以我并不惊奇在十一月举行的Puget Sound 美国化学工程师学会 (AIChE) 会议将重点放到了Amgen的细胞发酵工艺过程上。Amgen的Anna Senczuk在此次AIChE会议上作了这一报告:颗粒分布和胆固醇高低作为细胞培养菌絮凝和过滤性能的预报因子

随着近年来细胞发酵技术的提高,大部分细胞发酵过程每釜所含细胞密度较高。细胞越多蛋白质含量越高,产物产率便增加。对具有大量细胞要警戒的是去除细胞的工艺过程。事实证明传统的细胞去除方法效率不佳。

Anna Senczuk的研究工作一部分是确定如何应用絮凝方法来除去来自细胞培养菌的固体。絮凝技术已在各种工业领域使用多年,包括水清洁、纸浆/矿浆、和造纸业。作为细胞去除项目的一部分,Anna研究并开发出了一个新型的、改进了的、使用絮凝和传统细胞去除技术的工艺过程。

在此项目中, Anna的研究目的包括:

  • 理解絮凝在其工艺过程中如何起作用
  • 颗粒分布分析能否帮助优化絮凝?
  • 颗粒分布与过滤特性之间是否直接相关?

Anna用在她研究中的各种方法包括FBRM (聚光反射测量), SHC过滤作为一种分析手段,和脂类分析(过滤器的筛选和吸附特性)。FBRM是一个原位颗粒特性分析技术,测量工艺过程中真实存在的细胞絮凝粒/碎片。实时测量所得信息然后与其它技术的结果(像过滤速率 )相关联,从而对工艺过程获得理解并予以优化。

(此前我也曾讨论过絮凝过程,请看我的博贴:Why Is Canada Reducing Oil Sand Tailing Ponds?

AIChE征集结晶技术报告

美国化学工程师学会(AIChE)2011年会将在十月16-21 日于Minneapolis, MN 举行,有几个分会将重点讨论结晶于蒸发。

2011 AIChE
Bing-Shiou Yang (Principal Engineer, Boehringer Ingelheim) 和我将主持用于结晶开发与生产的PAT 分会。本分会欢迎新进的把工艺过程分析技术(PAT)应用于结晶工艺过程开发和生产的技术报告。 PAT应用技术可包括各种光谱分析法(FTIR, NIR, Raman)、颗粒与计数技术、以及其它不同在线监测或传感技术。尤其感兴趣的是驱动结晶过程开发的创新性途径和手段。 Continue reading

AIChE Call For Crystallization Papers

The 2011 American Institute of Chemical Engineers (AIChE) Annual Meeting – to be held October 16-21 in Minneapolis, MN – features a number of sessions on crystallization and evaporation.  Continue reading

PSAIChE Biotech: Optimize Flocculation With Real Time Particle Characterization

Since the Seattle area is well known for biotech, I was not surprised when the November Puget Sound American Institute of Chemical Engineers (AIChE) meeting focused on the cell fermentation process at Amgen.   The AIChE meeting featured the presentation by Amgen’s Anna Senczuk:  Continue reading

AIChE 2010中的PAT–实时监测制粒过程和滚动致密过程

在盐湖城举行的2010 美国化工学会 (AIChE) 年会中,一些出席良好的分会与质量源于设计(QbD) 和工艺过程分析技术(PAT)相关。

美国化工学会年会最近,我在PharmaQbD 博客上以嘉宾身份发表了一个对QbD 和PAT 的简要回顾,题为“如果QbD 是地图,PAT即是GPS”。本博客贴文的出发点是QbD 和PAT以互补的方式来应用是最有效的。在AIChE年会中,可以看到许多好的例子,它们基于将通过QbD实验开发出来的工艺模型应用到后期开发和生产上,在PAT的指导下进行实时监测和控制。

许多讨论关注到药品制造的连续工艺过程,反映了制药生产技术的明显提高。然而,这种提高也同时证实了对(通过QbD)理解工艺过程的需求,以便与工艺过程监测(PAT的一关键要素)相匹配。例如,好几个报告介绍了在滚动致密过程中连续监测颗粒大小的分布,从而提供测量和控制关键质量属性的潜在能力。颗粒(细粒)大小直接影响到粉末的流动性和可压性,通过导致最终制剂的溶出/解体特征的不同进而影响到原料药的生物活性。

如果您对应用工艺过程测量技术来实时理解颗粒和制粒系统感兴趣,我向您建议以下两个免费历届网络研讨会:

2010 Fall Meeting Highlights

Now that the busy fall meeting season has come to an end, I wanted to take the opportunity to quickly revisit some highlights that my colleagues and I noted: Continue reading