Tag Archives: Adrian Burke

Synthetic Chemistry Beyond The Round Bottom Flask

While analytical technologies that support synthetic organic chemistry in the laboratory have changed dramatically, chemical synthesis itself has remained largely unchanged for over fifty years.  During that time, the round bottom flask has been the workhorse for organic chemists in the synthesis lab. Continue reading

美国化学学会 (ACS)流动化学资源

我在于Anaheim举办的第241届美国化学学会(ACS)年会与会展之前提到过,会上有用实时流动化学与原位分析实现并优化化学反应的专题讨论。

连续流动反应器这一专题研讨列举了各种化学反应案例,从而显示如何利用连续流动化学技术与原位分析相结合来快速优化化学反应。因为流动化学是当今有机化学领域里最热门的议题之一,并且前二十大制药公司都在不断地向流动技术中进行明显投入,我想让大家知道你们已经可以获得ACS流动化学专题讨论的资料了。

流动反应器技术与原位分析的结合将流动化学提升到一个新的高度。产物、副产物、及活性中间体的生成全都得以跟踪,并且用这种信息作实时的判断和有依据的决定,从而使整个系统的操作条件得到优化。

下面列出的是一些对你可能有帮助的其它关于连续流动化学的信息:

American Chemical Society (ACS) Flow Chemistry Resources

As I mentioned prior to the 241st American Chemical Society (ACS) National Meeting and Exposition in Anaheim, there was an Enabling and Optimizing Chemical Reactions in Real Time Flow Chemistry and In Situ Analysis workshop.  Continue reading

金属催化反应中使用原位光谱

金属催化反应数年来已是学术研究上的一个关键课题,不仅针对有关科学兴趣还涉及很多已有工业重要性的反应。

ReactIR如今研究人员们所面临的部分主要挑战包括需要准确地确定反应的起始点与终点,同时获得足够的反应信息从而充分理解、定性并优化化学反应。加上需要用有限的资源在更短的时间内完成大量的研究试验,这致使研究人员们为成功地完成工作而寻找创新的方法来获得他们所需的信息。

原位红外 (IR) 光谱越来越多地被用于有机合成化学,因为它具备提供关键信息的能力,它所提供的信息可使研究人员们解释众多各种反应的机理、动力学及途径。

新的 金属催化反应中使用原位光谱的白皮书重点列举了学术界用原位IR光谱作为一种智能工具来揭示其研究中的关键参数的案例。作者突出了对应用原位IR光谱的描述、并说明它是如何帮助研究人员们解答关键问题的。所引用的工作来自Emory大学(美国)、Albany大学 (SUNY,美国)、Buffalo大学(SUNY,美国)、Bari大学(意大利)、 武汉大学 (中国)、Stockholm大学(瑞典)的研究组。

Is Lithium Salt More Like Organolithium Or Azaenolate?

2-Lithio-3,3-dimethyl-2-oxazolinyloxirane: Carbanion or Azaenolate?

Vito Capriati*, Saverio Florio*, Renzo Luisi, Filippo Maria Perna and Agnese Spina
Dipartimento Farmaco-Chimico, Università di Bari, Consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy; J. Org. Chem., 2008, 73 (24), pp 9552–9564.

Structure, Configurational Stability and Stereodynamics in Solution
During this work, Vito Capriati, Saverio Florio and colleagues at the University of Bari in Italy used in situ Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectroscopy together to give a better insight into the stability of lithium salt and to ultimately answer the question:

“Is the lithium salt more like an organolithium or is it more like an azaenolate?”
Continue reading

Heterobimetallic Bi−Rh Paddlewheel Carboxylates as Catalysts for Metal Carbenoid Transformations

Jørn Hansen†, Bo Li‡, Evgeny Dikarev‡, Jochen Autschbach§ and Huw M. L. Davies*†
† Department of Chemistry, Emory University, 440 Atwood Hall, 1515 Dickey Drive, Atlanta, Georgia 30322 ‡ Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222 § Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260-3000 J. Org. Chem., 2009, 74 (17), pp 6564–6571

Combined Experimental and Computational Studies
This paper reports on work by Huw Davies and colleagues at Emory University in Atlanta, GA. During their work, Professor Davies and his colleagues evaluate the catalytic activity of heterobimetallic Bi-Rh carboxylate complexes in metal carbenoid chemistry and cyclopropanation reactions. Continue reading

Metal Catalyzed Transformations Using In Situ Spectroscopy

Metal Catalyzed Transformations have been a key topic in academic research for a number of years, both for their scientific interest, as well as the large number of reactions that have become important to industry. Continue reading

Upcoming Continuous Flow Chemistry Events

Regular visitors to this blog will be familiar with recent continuous flow chemistry events in what I consider to be a very exciting, fast-developing area of chemistry. When I was reading the recent blog post regarding the upcoming Pfizer Flow Technology Expo, I thought about other upcoming flow chemistry events, including: Continue reading

4th Annual Uniqsis Flow Chemistry Symposium

Uniqsis British ConsulateBy no means am I a flow chemistry expert, but as probably the case for many other chemists, continuous processing has piqued my interest over the past few years. Continue reading

Let Chemists Do What Chemists Do Best

During the 2010 Fall American Chemical Society (ACS) meeting in Boston, Professor Steven V. Ley presented a novel approach to the use of flow chemistry as a synthetic technique. Continue reading