Tag Archives: active pharmaceutical ingredients

Improve Organic Synthesis in 4 Ways

After writing last week regarding recent advances to improve chemical development in the pharmaceutical industry, there were a lot of discussions about the top 4 ways to improve organic synthesis. Continue reading

NESACS’s Bench to Plant Symposium

NESACS SymposiumUpon returning to the Boston area after a number of years away, I was very much looking forward to attending The Northeastern Section of the American Chemical Society (NESACS)’s Advances in Chemical Sciences “Bench to Plant” Symposium for the first time.  Held in Cambridge on October 22, about 100 scientists from the local area gathered for the one day Symposium focusing on Process R&D Chemistry, Organic Synthesis, and New Synthetic Methodology.

Some highlights of the top-notch presentations included:

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Why Measure Particle or Droplet Distribution in Process or Development?

After last week’s introduction to liquid dosage formulations, I wanted to follow-up with: why measure the particle or droplet distribution in process or in development? Continue reading

What are Liquid Dosage Formulations?

Often, I hear questions surrounding what are liquid dosage formulations.  I thought I might take the opportunity to provide a short introduction to liquid dosage formulations.  Liquid dosage formulations may be in the form of suspensions or syrups, metered dosed inhalers (MDIs), or creams or lotions. All of these systems would typically have particles present or droplets present in their formulations. There could also be parentals, such as injections or intravenous infusions, which may be particle free. Continue reading

Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries

Last week, John Tedesco and I had the privilege to attend the 3rd International Symposium on Green Processing in the Pharmaceutical & Fine Chemical Industries in Boston, MA. Continue reading

Early Phase Implementation of Process Analytical Technology (PAT) Tools in Chemical Development

In the pharmaceutical industry, the pressure to decrease development times for new chemical entities is common.  During the recent 17th International Process Development Conference, Terry Connelly of Pfizer discussed this particular challenge during the presentation “Examples of Early Phase Implementation of Process Analytical Technology (PAT) Tools:  Meeting Short Term Goals While Setting the Stage for Long-Term Process Understanding and Control”.
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The Future of Chemical Research and Development: The Demise of the Round Bottomed Flask

ISPE-New-England-Chapter-BioPharma-ConferenceLast Thursday, May 6th, I attended the ISPE (International Society for Pharmaceutical Engineering) New England Chapter Biopharma 2010 Conference held in Warwick, Rhode Island.  A presentation was given by Geraldine Taber, Pfizer’s Global Technology Group Leader titled “Demise of the Round-Bottomed Flask – How new Battle Tools in the Lab of the Future are delivering value for R&D”.

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