Tag Archives: Active Pharmaceutical Ingredient

Introduction to Crystallization & Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture. Salt and sugar are delivered to our dinner tables as crystals. The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

Introduction to Crystallization and Precipitation

Crystallization touches every aspect of our lives from the foods we eat and the medicines we take, to the fuels we use to power our communities. The majority of pharmaceutical products go through at least one crystallization step during their manufacture.  Salt and sugar are delivered to our dinner tables as crystals.  The unwanted crystallization of gas hydrates played a role in the recent Deepwater Horizon oil spill. Continue reading

Online Monitoring Particle Milling – EMS and IIPF

I recently had the pleasure of collaborating with a group of very talented scientists at EMS and International Institute of Pharmaceutical Research (IIPF).  EMS and IIPF are two pharmaceutical companies based in Hortolândia, a city roughly 100 miles northwest of Sao Paulo, Brazil. We worked on an interesting project where FBRM was used to track Active Pharmaceutical Ingredient (API) particle size reduction during wet milling. Traditionally, offline laser diffraction had been used to track this process; however this approach proved to be time consuming, prone to inaccuracy and potentially hazardous. Continue reading