Upon returning to the Boston area after a number of years away, I was very much looking forward to attending The Northeastern Section of the American Chemical Society (NESACS)’s Advances in Chemical Sciences “Bench to Plant” Symposium for the first time. Held in Cambridge on October 22, about 100 scientists from the local area gathered for the one day Symposium focusing on Process R&D Chemistry, Organic Synthesis, and New Synthetic Methodology.
Some highlights of the top-notch presentations included:
Commitment and investment to develop the use of Process Analytical Technology (PAT) is a primary reason why the pharmaceutical industry is able to find ways to streamline and improve manufacturing processes. However, there are significant challenges when implementing Process Analytical Technology (PAT) into larger-scale manufacturing, such as compatibility of measurement instrumentation with classified hazardous areas and the existing processing infrastructure. Even more important is how to sample the chemistry in situ. The majority of reactor vessels in commission today lack suitable entry points for the measurement technology that requires there modification or replacement, which can significantly increase project costs or prohibit implementation entirely. Continue reading →
This week, the United Kingdom Automated Synthesis Forum (UKASF)will be held at Novartis in Horsham. Ian Clemens of Novartis is the Chair of the UKASF and will deliver the opening remarks to begin the Forum on Wednesday.
On Tuesday, November 2, METTLER TOLEDO held its 1st Symposium in Cambridge, MA, hosted by Novartis Institutes for BioMedical Research (NIBR). The success of the Symposium went beyond expectations: 65 scientists representing a large variety of small companies (CoNCERT, Cubist, Tetraphase), larger companies (Pfizer, Dow, Amgen), and research institutions (Massachusetts Institute of Technology) attended the event. The main themes of the Symposium were crystallization and process safety. Des O’Grady and I started by giving an overview of the technologies later covered by the industry speakers: Focused Beam Reflectance Measurement (FBRM®), Particle Video Microscope (PVM®), EasyMax™, RC1, and ReactIR™. Continue reading →
As 2010 comes to a close, I am taking one more opportunity to review the role that real-time in situ FTIR has played in advancing chemical research in academia on November 17. This online seminar is the sixth installment in the series: Recent Advances in Organic Chemistry Research in Academia Through the Use of Real-time In Situ FTIR. In preparing for this webinar, I have come realize how pervasive the use of in situ mid-IR is across a wide range of chemistry disciplines. For convenience sake, I focused only on the American Chemical Society (ACS) Journals research articles.
Jon Goode, Nigel Gaunt, and I attended the 1st Annual Royal Society of Chemistry (RSC)/Society of Chemical Industry (SCI) Continuous Flow Symposium held last week at GlaxoSmithKline in Stevenage, United Kingdom. Considering that this was the first time this particular event was held, it was very well attended. This was yet another reminder of what seems to be an ever increasing interest in continuous flow. Continue reading →
My colleague, Rodrigo Maciel, and I had the opportunity to attend the Mary K. O’Connor Process Safety Center 2010 International Symposium October 26 to 28 at Texas A&M University in College Station, Texas. This process safety conference had about 400 attendees, which included representation from government agencies (OSHA, Chemical Safety Board), Chemical Engineering Professors from around the globe, Safety Consultants, and Process Safety Managers and Scientists from Petrochemical and Chemical companies. The event featured 106 presentations and 20 exhibitors. Continue reading →
This is the first blog post in a 2 part series in which I will discuss the real-time monitoring of bio-based chemical synthesis.
Biocatalysis continues to evolve, with the application of recombinant organisms or isolated enzymes designed to catalyze specific chemical reactions – often with highly regiospecific and stereospecific conversions. In the optimization of any chemical synthesis reaction – by traditional or biocatalyzed routes – it is not enough to simply report the yield and the enantiameric excess (ee), the kinetics of the reaction must also be considered. Understanding how the kinetics are affected by conditions such as pH and temperature allows optimization of biocatalysis through the identification of operating conditions that can ensure a maximum yield and desired ee in a timely manner. Continue reading →
Traditionally, organic chemistry students have been instructed to analyze reactions using standard offline analytical methods, such as High-Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR) Spectroscopy, and Gas Chromatography (GC).