Category Archives: iC Kinetics

Is Lithium Salt More Like Organolithium Or Azaenolate?

2-Lithio-3,3-dimethyl-2-oxazolinyloxirane: Carbanion or Azaenolate?

Vito Capriati*, Saverio Florio*, Renzo Luisi, Filippo Maria Perna and Agnese Spina
Dipartimento Farmaco-Chimico, Università di Bari, Consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy; J. Org. Chem., 2008, 73 (24), pp 9552–9564.

Structure, Configurational Stability and Stereodynamics in Solution
During this work, Vito Capriati, Saverio Florio and colleagues at the University of Bari in Italy used in situ Infrared (IR) and Nuclear Magnetic Resonance (NMR) spectroscopy together to give a better insight into the stability of lithium salt and to ultimately answer the question:

“Is the lithium salt more like an organolithium or is it more like an azaenolate?”
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Metal Catalyzed Transformations Using In Situ Spectroscopy

Metal Catalyzed Transformations have been a key topic in academic research for a number of years, both for their scientific interest, as well as the large number of reactions that have become important to industry. Continue reading

Symposium on Process Safety and Crystallization

On Tuesday, November 2, METTLER TOLEDO held its 1st Symposium in Cambridge, MA, hosted by Novartis Institutes for BioMedical Research (NIBR). The success of the Symposium went beyond expectations: 65 scientists representing a large variety of small companies (CoNCERT, Cubist, Tetraphase), larger companies (Pfizer, Dow, Amgen), and research institutions (Massachusetts Institute of Technology) attended the event. The main themes of the Symposium were crystallization and process safety. Des O’Grady and I started by giving an overview of the technologies later covered by the industry speakers: Focused Beam Reflectance Measurement (FBRM®), Particle Video Microscope (PVM®), EasyMax™, RC1, and ReactIR™. Continue reading

Mary K. O’Connor Process Safety Center 2010 International Symposium

My colleague, Rodrigo Maciel, and I had the opportunity to attend the Mary K. O’Connor Process Safety Center 2010 International Symposium October 26 to 28 at Texas A&M University in College Station, Texas.  This process safety conference had about 400 attendees, which included representation from government agencies (OSHA, Chemical Safety Board), Chemical Engineering Professors from around the globe, Safety Consultants, and Process Safety Managers and Scientists from Petrochemical and Chemical companies.  The event featured 106 presentations and 20 exhibitors. Continue reading

Chemical Process Development Symposium at Novartis

Cambridge, Massachusetts is a unique place due to having one of the largest (per capita) and most impressive populations of scientists and engineers in the world.  Because of this, Cambridge is recognized as a global hub for biotechnology.  This makes the Boston area an attractive venue to organize a chemical process development gathering. Continue reading

Optimize Chemistry Via Kinetic Analysis

On October 20, Professor Donna Blackmond will present the second part of a webinar series – Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions. Continue reading

Why is Kinetic Data Valuable?

Arguably, kinetics is one of the least popular subjects in academic or industrial research.  During her recent webinar – Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions, Donna Blackmond reiterated why having kinetic data can be valuable:
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How To Streamline Kinetics Studies Using Reaction Progress Kinetic Analysis (RPKA)

Check out this 2-minute video for a quick tour of how Reaction Progress Kinetic Analysis (RPKA) and iC Kinetics can streamline and accelerate kinetics studies.

httpv://www.youtube.com/watch?v=lo2K-hdf8xs

For a more detailed look at RPKA, check out this Free On-Demand Webinar (presented by Prof. Donna Blackmond): Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions.

The Reaction Progress Kinetic Analysis (RPKA) Methodology, pioneered by Prof. Donna G. Blackmond of The Scripps Research Institute, requires far fewer reaction progress experiments than the classic kinetics approach. It accomplishes this by exploiting the extensive data available from accurate in-situ reaction monitoring under synthetically relevant conditions. The process is further streamlined by iC Kinetics software that automates the math and provides powerful visualizations to guide scientists to an understanding of reaction mechanisms and the selection of optimal reaction conditions.

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